{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:01:03Z","timestamp":1787166063131,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":133,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lymphedema refers to the accumulation of protein-rich fluid in the interstitial spaces. This can occur secondary to congenital malformation of the lymphatic channels or nodes or as a result of an insult that damages appropriately formed channels and nodes. Stagnant, protein-rich lymph initiates an inflammatory response that leads to adipocyte proliferation, fibrous tissue deposition, and increased susceptibility to infections. The end result is permanent disfigurement and dermal changes. Early and accurate diagnosis is essential, since lymphedema is a chronic and progressive problem. When lymphedema affects the lower extremity, it is important to manage it in a way that preserves function and mobility. Early diagnosis also allows for a proactive rather than reactive approach to treatment and utilization of novel physiologic procedures, such as lymphovenous anastomosis and vascularized lymph node transfer. Such interventions slow down disease progression and reduce morbidity by allowing the surgeon to salvage the remaining functional lymphatic channels. When physiologic procedures fail or when faced with a delayed presentation, the addition of excisional procedures can provide a more comprehensive treatment of this debilitating disease. The aim of this article is to review the most current concepts in the surgical management of lower extremity lymphedema.<\/jats:p>","DOI":"10.1055\/s-0039-1688537","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T20:42:29Z","timestamp":1557866549000},"page":"081-092","source":"Crossref","is-referenced-by-count":41,"title":["Surgical Management of Lower Extremity Lymphedema: A Comprehensive Review"],"prefix":"10.1055","volume":"52","author":[{"given":"Pedro","family":"Ciudad","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, Peru"},{"name":"Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Diya","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota, United Sates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouchammed","family":"Agko","sequence":"additional","affiliation":[{"name":"Section of Plastic Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony C.T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota, United Sates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar J.","family":"Manrique","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota, United Sates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Rom\u00e1n","family":"L.","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine, National Cancer Institute of Peru (INEN), Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Reynaga","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, National Cancer Institute of Peru (INEN), Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Maruccia","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,5,14]]},"container-title":["Indian Journal of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1688537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T18:34:15Z","timestamp":1559327655000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1688537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,5,31]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1688537","relation":{},"ISSN":["0970-0358","1998-376X"],"issn-type":[{"value":"0970-0358","type":"print"},{"value":"1998-376X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}