{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:47:47Z","timestamp":1766738867352,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":142,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J Pediatr Surg Rep"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Background\u2003Pulmonary Langerhans's cell histiocytosis (PLCH) is a rare cause of interstitial lung disease in children and more than half of the cases are bilateral. Persistent respiratory distress due to spontaneous pneumothorax (SP) in bilateral PLCH may refractory to conservative treatment and posed a great challenge to surgical modalities. A 3-year-old boy with SP due to bilateral PLCH is presented to discuss the surgical options of recurrent and refractory PLCH cases in children.<\/jats:p><jats:p>\n            Case Report\u2003The patient was admitted to the emergency department with severe respiratory distress and SP. After chest tube insertion, biopsy from neck mass revealed Langerhans's cell histiocytosis. Chemotherapy including vinblastine and prednisone was initiated. Due to persistent respiratory difficulty and air leaks, talc pleurodesis and thoracoscopic bullae excision with pleural decortication were performed. Two months after the admission, due to nosocomial infection and severe respiratory distress, extracorporeal membranous oxygenation (ECMO) support was initiated. The patient was died of ECMO complications on 24th day of ECMO.<\/jats:p><jats:p>\n            Conclusion\u2003Despite the use of chemotherapy and surgical excision of cystic lesions, bilateral PLCH in children may have lethal outcome. Other treatment options including respiratory support with ECMO and lung transplantation should be considered as last resort of treatment alternative in persistent cases.<\/jats:p>","DOI":"10.1055\/s-0039-1688771","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T18:31:01Z","timestamp":1558636261000},"page":"e8-e11","source":"Crossref","is-referenced-by-count":7,"title":["Bilateral Pulmonary Langerhans's Cell Histiocytosis is Surgical Challenge in Children: A Case Report"],"prefix":"10.1055","volume":"07","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-6042","authenticated-orcid":false,"given":"Tutku","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"\u00d6zy\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-7793","authenticated-orcid":false,"given":"\u00d6zlem Boybeyi","family":"T\u00fcrer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra","family":"\u00c7akmakkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilgehan","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diclehan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pathology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benan","family":"Bayrak\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nural","family":"Kiper","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Aky\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,23]]},"container-title":["European Journal of Pediatric Surgery Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1688771.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T18:31:02Z","timestamp":1558636262000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1688771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,5,23]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1688771","relation":{},"ISSN":["2194-7619","2194-7627"],"issn-type":[{"type":"print","value":"2194-7619"},{"type":"electronic","value":"2194-7627"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}