{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:47:42Z","timestamp":1777531662070,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to assess the probable relationship between icter in neonates with ABO incompatibility hemolysis and UGT1A1 gene polymorphism.<\/jats:p><jats:p>\n          Study Design\u2003There were 65 ABO hemolytic disease of the newborn (HDN) neonates of full term in the study group and 82 non-ABO HDN neonates of full term in the compared group. We tested the UGT1A1 gene mutation of neonates of ABO HDN and non-ABO HDN. We compared the incidence of hyperbilirubinemia between neonates with and without UGT1A1 mutations in the ABO HDN and non-ABO HDN, to determine the relationship between icter in neonates with ABO HDN and UGT1A1 gene polymorphism. SPSS 13.0 were used to analyze those two groups' data.<\/jats:p><jats:p>\n          Results\u2003There was statistically significant difference of the serum bilirubin level between the Gly71Arg homozygous and no mutation group in the ABO HDN patients (p\u2009&lt;\u20090.05). When hyperbilirubinemia was defined as serum bilirubin concentration &gt;342 \u03bcmol\/L, the incidence of hyperbilirubinemia between patients of UGT1A1 and non-UGT1A1 mutations in the ABO HDN group was significantly different (p\u2009&lt;\u20090.05). But in the non-ABO HDN group, no significant difference was found.<\/jats:p><jats:p>\n          Conclusion\u2003Individuals with Gly71Arg homozygous contributed to their hyperbilirubinemia in ABO HDN patients.<\/jats:p>","DOI":"10.1055\/s-0039-1688816","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T23:00:27Z","timestamp":1557874827000},"page":"652-658","source":"Crossref","is-referenced-by-count":5,"title":["Study of Gilbert's Syndrome-Associated UGT1A1 Polymorphism in Jaundiced Neonates of ABO Incompatibility Hemolysis Disease"],"prefix":"10.1055","volume":"37","author":[{"given":"Yingfang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,14]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1688816.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T22:57:40Z","timestamp":1587769060000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1688816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,4,24]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1688816","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}