{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:31:48Z","timestamp":1768516308627,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to describe normal C-reactive protein (CRP) levels of newborns diagnosed with hypoxic-ischemic encephalopathy (HIE) and assess the influence of therapeutic hypothermia (TH) and the severity of HIE.<\/jats:p><jats:p>\n            Study Design\u2003We prospectively recruited infants \u226535 weeks of gestational age diagnosed with HIE from 2000 to 2013 and compared CRP levels in the first 120 hours of life according to the severity of HIE and the use of TH, which was introduced in 2009.<\/jats:p><jats:p>\n            Results\u2003Moderate HIE was diagnosed in 115 newborns, severe HIE in 90 (hypothermia was performed in 151 cases), and mild HIE in 20. Cooled newborns showed lower levels of CRP in the first 34 hours, but reached higher median maximum CRP levels (15.4 vs. 8.5 mg\/L), and at a significantly older age (53 vs. 17 hours). Levels of CRP in mild HIE were lower than those of moderate\u2013severe forms. Moderate and severe HIE had similar CRP levels, but time to maximum CRP was significantly less in moderate cases.<\/jats:p><jats:p>\n            Conclusion\u2003CRP levels of mild HIE are similar to healthy newborns, while CRP elevations can be expected in newborns with moderate\u2013severe HIE. TH produced a slower rise, with a higher and late maximum CRP peak level.<\/jats:p>","DOI":"10.1055\/s-0039-1688818","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T22:39:41Z","timestamp":1558651181000},"page":"722-730","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Hypothermia and Severity of Hypoxic-Ischemic Encephalopathy in the Levels of C-Reactive Protein during the First 120 Hours of Life"],"prefix":"10.1055","volume":"37","author":[{"given":"Amaia","family":"Cilla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Burgos University Hospital, Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Arnaez","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Burgos University Hospital, Burgos, Spain"},{"name":"NeNe Foundation, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Benavente-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"NeNe Foundation, Spain"},{"name":"Neonatology Unit, Puerta Del Mar University Hospital, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Virgen De La Concha Hospital, Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Vega","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Burgos University Hospital, Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sim\u00f3n","family":"Lubi\u00e1n-L\u00f3pez","sequence":"additional","affiliation":[{"name":"NeNe Foundation, Spain"},{"name":"Neonatology Unit, Puerta Del Mar University Hospital, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Garcia-Alix","sequence":"additional","affiliation":[{"name":"NeNe Foundation, Spain"},{"name":"Institut de Recerca Pediatrica Sant Joan de D\u00e8u, Sant Joan de D\u00e8u Hospital, Barcelona, Spain"},{"name":"Universitat de Barcelona, Barcelona, Spain"},{"name":"CIBER of Rare Diseases (CIBERER), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,23]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1688818.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T22:39:08Z","timestamp":1590014348000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1688818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,23]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,5,20]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1688818","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,23]]}}}