{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:15:37Z","timestamp":1783091737225,"version":"3.54.6"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HHSN267200603423"],"award-info":[{"award-number":["HHSN267200603423"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HHSN267200603424"],"award-info":[{"award-number":["HHSN267200603424"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HHSN267200603426"],"award-info":[{"award-number":["HHSN267200603426"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n            Objective\u2003We characterized lipid trajectories and investigated lipids and rate of pregnancy lipid change with the risk of pregnancy loss or preterm delivery &lt;37 weeks.<\/jats:p><jats:p>\n            Study Design\u2003In a secondary analysis of 337 women with one to two prior losses assigned to placebo in a randomized controlled trial at four centers (2007\u20132012), cholesterol, low- and high-density lipoprotein cholesterol (HDL-C), and triglycerides were measured up to 6 months prepregnancy (time 0) and pregnancy up to 7 visits. Trajectories were created using linear mixed models. Multivariable logistic regression with adjustment for maternal characteristics and cholesterol was performed.<\/jats:p><jats:p>\n            Results\u2003Lipids decreased from prepregnancy to 4 to 5 weeks, followed by an increase, and were biphasic or triphasic depending on the lipid component. Between 4 and 8 weeks, for every 1-unit increase in HDL-C, there was a 22% decreased odds of loss &lt;14 weeks (odds ratio: 0.78; 95% confidence interval: 0.60, 0.99) and 24% decreased odds of loss or preterm delivery 14 to &lt;37 weeks (odds ratio: 0.76; 95% confidence interval: 0.60, 0.96).<\/jats:p><jats:p>\n            Conclusion\u2003There were no associations with other lipid components or other time points. An impaired rise of HDL-C early in pregnancy may signal maladaptation to pregnancy that is associated with pregnancy loss or preterm delivery.<\/jats:p>","DOI":"10.1055\/s-0039-1689000","type":"journal-article","created":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T22:30:53Z","timestamp":1559514653000},"page":"914-923","source":"Crossref","is-referenced-by-count":16,"title":["Maternal Serum Lipid Trajectories and Association with Pregnancy Loss and Length of Gestation"],"prefix":"10.1055","volume":"37","author":[{"given":"Katherine L.","family":"Grantz","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Elmi","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"},{"name":"The Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Catov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science and Department of Epidemiology, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Sjaarda","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Albert","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"},{"name":"Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,6,2]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1689000.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T01:07:44Z","timestamp":1593220064000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1689000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,2]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,6,24]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1689000","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,2]]}}}