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The higher risks of neurodevelopmental delay, metabolic syndrome, and cardiovascular illness associated with FGR impose a shift on the focus during pregnancy. New methodological approaches, like metabolomics, can provide novel biomarkers for intrauterine fetal development. Recent evidence on metabolites involved with fetal growth and weight show a consistent role played by lipids (especially fatty acids), amino acids, vitamin D and folic acid. Fetal energy source and metabolism, structural functions, and nervous system functioning need further evaluations in different populations. In the near future, the establishment of a core set of outcomes for FGR studies may improve the identification of the role of each metabolite in its development. Thus, we will concretely progress with the perspective of a translational capacity of metabolomics for this condition.<\/jats:p>","DOI":"10.1055\/s-0039-1692126","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:08:45Z","timestamp":1561680525000},"page":"454-462","source":"Crossref","is-referenced-by-count":9,"title":["New Approaches to Fetal Growth Restriction: The Time for Metabolomics Has Come"],"prefix":"10.61622","volume":"41","author":[{"given":"Debora Farias Batista","family":"Leite","sequence":"additional","affiliation":[{"name":"Departament of Obstetrics and Gynecology, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, SP, Brazil"},{"name":"Department of Mother and Child Health, Universidade Federal de Pernambuco, Recife, PE, Brazil"},{"name":"Hospital Cl\u00ednico, Universidade Federal de Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-8445","authenticated-orcid":false,"given":"Jos\u00e9 Guilherme","family":"Cecatti","sequence":"additional","affiliation":[{"name":"Departament of Obstetrics and Gynecology, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/uog.14818","article-title":"Impact of cerebral redistribution on neurodevelopmental outcome in small-for-gestational-age or growth-restricted babies: a systematic review","volume":"46","author":"S Meher","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/bmj.306.6875.422","article-title":"The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life","volume":"306","author":"D J Barker","year":"1993","journal-title":"BMJ"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"e0190483","DOI":"10.1371\/journal.pone.0190483","article-title":"The associations between adult body composition and abdominal adiposity outcomes, and relative weight gain and linear growth from birth to age 22 in the Birth to Twenty Plus cohort, South Africa","volume":"13","author":"A Prioreschi","year":"2018","journal-title":"PLoS One"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/obr.12109","article-title":"Size at birth and abdominal adiposity in adults: a systematic review and meta-analysis","volume":"15","author":"G V Ara\u00fajo de Fran\u00e7a","year":"2014","journal-title":"Obes Rev"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.clnu.2015.11.010","article-title":"The famine exposure in early life and metabolic syndrome in adulthood","volume":"36","author":"N Wang","year":"2017","journal-title":"Clin Nutr"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.maturitas.2011.06.017","article-title":"Hungry in the womb: what are the consequences? 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