{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:33:02Z","timestamp":1784863982963,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n            Objective\u2003The aim of this study was to establish the effects of treprostinil in congenital diaphragmatic hernia (CDH) patients with persistent pulmonary hypertension (PHT) after 1 week of treatment. Drug effects were assessed by oxygenation index (OI), clinical end points, serial biochemical markers, and pre- and posttreatment echocardiogram. Treatment complications were also described.<\/jats:p><jats:p>\n            Study Design\u2003This is a quasi-experimental study of neonates with PHT admitted to the NICU within 48 hours showing persistent clinical instability, receiving mechanical ventilation with FiO2\u2009&gt;\u200960%, milrinone therapy, and inhaled nitric oxide. Clinical data were compared before and after treprostinil treatment.<\/jats:p><jats:p>\n            Results\u2003Seventeen neonates met the inclusion criteria. Median age was 17 days. Before treatment, median OI was 20 (IQR: 12\u201327). Suprasystemic PHT was estimated by echocardiogram in 8\/17 patients; the rest were systemic. After 1 week of treatment, 15\/17 patients were alive and median OI was 8 (IQR: 5\u201312, p\u2009=\u20090.0089). There were no statistically significant changes in laboratory data. Echocardiogram still showed suprasystemic PHT in 20% of patients. Adverse effects included hypotension, hematoma at the infusion site, and surgical persistent ductus arteriosus (PDA) closure in 4\/17 patients. Fourteen patients were discharged. The median treatment time was 61 days.<\/jats:p><jats:p>\n            Conclusion\u2003Treprostinil was well tolerated with satisfactory clinical response. Further studies are required to identify early responder subgroups.<\/jats:p>","DOI":"10.1055\/s-0039-1692182","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T22:54:05Z","timestamp":1559775245000},"page":"939-946","source":"Crossref","is-referenced-by-count":14,"title":["Neonates Effects and Tolerability of Treprostinil in Hypertension with Persistent Pulmonary"],"prefix":"10.1055","volume":"37","author":[{"given":"Mariela","family":"Jozefkowicz","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children's Hospital SAMIC Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora Fabiana","family":"Haag","sequence":"additional","affiliation":[{"name":"Cardiology Department, Children's Hospital SAMIC Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Mazzucchelli","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children's Hospital SAMIC Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Salgado","sequence":"additional","affiliation":[{"name":"Cardiology Department, Children's Hospital SAMIC Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Fari\u00f1a","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children's Hospital SAMIC Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,6,5]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1692182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:10:37Z","timestamp":1593043837000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1692182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,6,24]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1692182","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]}}}