{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:57Z","timestamp":1787004897198,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Objective\u2003This study aimed to describe the experience with a protocol of therapeutic hypothermia (TH) in southern Brazil.<\/jats:p>\n                  <jats:p>Study Design\u2003Newborns with gestational age\u2009&gt;\u200935 weeks with evidence of perinatal asphyxia plus moderate or severe encephalopathy were recruited between March 2011 and November 2017. Whole-body hypothermia for 72 hours, starting within the first 6 hours of life was used. Survivors underwent magnetic resonance imaging (MRI) and electroencephalogram (EEG). The primary outcome was death during hospitalization and neurodevelopment assessed using the Bayley Scales of Infant Development III (BSID III) at 12 months of age.<\/jats:p>\n                  <jats:p>Results\u2003A total of 72 newborns were treated (41 with moderate encephalopathy and 31 with severe encephalopathy), of whom 16 died. MRI was performed in 56 patients, and 24 presented some alterations. Fifty-three patients had an EEG: 11 normal, 20 mildly altered, 12 moderately altered, and 10 severely altered. Forty patients were evaluated through BSID III: 45% presented with some delay in neurodevelopment, 8 (20%) had motor retardation, 15 (37.5%) had language delay, and 13 (32.5%) had a delay in cognitive development.<\/jats:p>\n                  <jats:p>Conclusion\u2003Mortality and adverse events were similar to those described in large randomized controlled trials. TH is a safe and an effective method of neurologic protection in asphyxiated newborns in a developing country when performed adequately.<\/jats:p>","DOI":"10.1055\/s-0039-1692388","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T18:47:16Z","timestamp":1559846836000},"page":"955-961","source":"Crossref","is-referenced-by-count":11,"title":["Outcome and Feasibility after 7 Years of Therapeutic Hypothermia in Southern Brazil"],"prefix":"10.1055","volume":"37","author":[{"given":"Renato S.","family":"Procianoy","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Corso","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna O.","family":"Schoenardie","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia P.F.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Longo","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Newborn Section, Department of Pediatrics, Universidade Federal do Rio Grande do Sul\/Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,6,6]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1692388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T20:10:39Z","timestamp":1593029439000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1692388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,6,24]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1692388","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}