{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:16:36Z","timestamp":1780575396714,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n            Background\u2003Patients with Philadelphia-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (MF), have a significant risk of venous thromboembolism (VTE). We aim to determine the trends in annual rates of VTE-related admissions, associated cost, length of stay (LOS), and in-hospital mortality in patients with MPN.<\/jats:p><jats:p>\n            Methods\u2003We identified patients with PV, ET, and MF from the Nationwide Inpatient Sample (NIS) database from 2006 to 2014 using ICD-9CM coding. Hospitalizations where VTE was among the top-three diagnoses were considered VTE-related. We compared in-hospital outcomes between VTE and non-VTE hospitalizations using chi-square and Mann\u2013Whitney U-test and used linear regression for trend analysis.<\/jats:p><jats:p>\n            Results\u2003We identified 1,046,666 admissions with a diagnosis of MPN. Patients were predominantly white (65.6%), females (52.7%), with a median age of 66 years (range: 18\u2013108). The predominant MPN was ET (54%). There was no difference in in-hospital mortality between groups (VTE: 3.4% vs. non-VTE: 3.2%; p\u2009=\u20090.12); however, VTE admissions had a longer LOS (median: 6 vs. 5 days; p\u2009&lt;\u20090.01) and higher cost (median: VTE US$32,239 vs. 28,403; p \u2264 0.01).<\/jats:p><jats:p>The annual rate of VTE admissions decreased over time (2006: 3.94% vs. 2014: 2.43%; p \u2264 0.01), compared with non-VTE\u2013related admissions.<\/jats:p><jats:p>\n            Conclusion\u2003In our study, VTE-related admissions had similar in-hospital mortality as compared with non-VTE\u2013related admissions. The rates of hospitalizations due to VTE have decreased over time but are associated with a higher cost and LOS. Newer risk assessment tools may assist in preventing VTE in high-risk patients and optimizing resource utilization.<\/jats:p>","DOI":"10.1055\/s-0039-1692988","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T18:40:27Z","timestamp":1563388827000},"page":"e203-e209","source":"Crossref","is-referenced-by-count":5,"title":["Trends and Inpatient Outcomes of Venous Thromboembolism-Related Admissions in Patients with Philadelphia-Negative Myeloproliferative Neoplasms"],"prefix":"10.1055","volume":"03","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-5217","authenticated-orcid":false,"given":"Vatsala","family":"Katiyar","sequence":"additional","affiliation":[{"name":"Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Uprety","sequence":"additional","affiliation":[{"name":"Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Mendez-Hernandez","sequence":"additional","affiliation":[{"name":"Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-8359","authenticated-orcid":false,"given":"Harry E.","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier A.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Zia","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,7,17]]},"container-title":["TH Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1692988.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T04:40:45Z","timestamp":1564548045000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1692988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,7,17]]},"published-print":{"date-parts":[[2019,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1692988","relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}