{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:33:22Z","timestamp":1784885602377,"version":"3.55.0"},"reference-count":23,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n            Objective\u2003To describe a series of cases of ovarian Sertoli-Leydig cell tumors (SLCTs).<\/jats:p><jats:p>\n            Methods\u2003Retrospective review of 12 cases of SLCT treated at the Hospital do C\u00e2ncer de Barretos, Barretos, state of S\u00e3o Paulo, Brazil, between October 2009 and August 2017.<\/jats:p><jats:p>\n            Results\u2003The median age of the patients was 31 years old (15\u201371 years old). A total of 9 patients (75.0%) presented symptoms: 8 (66.7%) presented with abdominal pain, 5 (41.7%) presented with abdominal enlargement, 2 (16.7%) presented with virilizing signs, 2 (16.7%) presented with abnormal uterine bleeding, 1 (8.3%) presented with dyspareunia, and 1 (8.3%) presented with weight loss. The median preoperative lactate dehydrogenase (LDH) was 504.5\u2009U\/L (138\u2013569\u2009U\/L), alpha-fetoprotein (AFP) was 2.0 ng\/ml (1.1\u201311.3 ng\/ml), human chorionic gonadotropin (\u03b2-hCG) was 0.6\u2009mUI\/ml (0.0\u20132.3\u2009mUI\/ml), carcinoembryonic antigen (CEA) was 0.9 ng\/ml (0.7\u20133.4 ng\/ml), and cancer antigen 125 (CA-125) was 26.0\u2009U\/ml (19.1\u2013147.0\u2009U\/ml). All of the tumors were unilateral and surgically treated. Lymphadenectomy was performed in 3 (25.0%) patients, but none of the three patients submitted to lymphadenectomy presented lymph node involvement. In the anatomopathological exam, 1 (8.3%) tumor was well-differentiated, 8 (66.7%) were moderately differentiated, and 3 (25.0%) were poorly differentiated. A total of 5 (55.6%) tumors were solid-cystic, 2 (22.2%) were purely cystic, 1 (11.1%) was cystic with vegetations, and 1 (11.1%) was purely solid, but for 3 patients this information was not available. The median lesion size was 14.2\u2009cm (3.2\u201323.5\u2009cm). All of the tumors were at stage IA of the 2014 classification of the International Federation of Gynecology and Obstetrics (FIGO). A total of 2 (16.7%) patients received adjuvant treatment; 1 of them underwent 3 cycles of paclitaxel and carboplatin every 21 days, and the other underwent 4 cycles of ifosfamide, cisplatin and etoposide every 21 days. None of all of the patients had recurrence, and one death related to complications after surgical staging occurred.<\/jats:p><jats:p>\n            Conclusion\u2003Abdominal pain was the most frequent presentation. There was no ultrasonographic pattern. All of the SLCTs were at stage IA, and most of them were moderately differentiated. Relapses did not occur, but one death related to the surgical staging occurred.<\/jats:p>","DOI":"10.1055\/s-0039-1693056","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T23:44:55Z","timestamp":1564098295000},"page":"440-448","source":"Crossref","is-referenced-by-count":15,"title":["Ovarian Sertoli-Leydig Cell Tumors: Epidemiological, Clinical and Prognostic Factors"],"prefix":"10.61622","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-0373","authenticated-orcid":false,"given":"Beatriz Guerreiro Ruiz","family":"Castro","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade de Barretos Dr. Paulo Prata, Barretos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano de P\u00e1dua","family":"Souza","sequence":"additional","affiliation":[{"name":"Gynecologic Clinical Oncology Department, Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo Mattos da Cunha","family":"Andrade","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Department, Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo de Andrade","family":"Vieira","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Department, Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dioc\u00e9sio Alves Pinto de","family":"Andrade","sequence":"additional","affiliation":[{"name":"InORP ONCOCL\u00cdNICAS Group (Instituto Oncol\u00f3gico de Ribeir\u00e3o Preto), Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo dos","family":"Reis","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Department, Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s004040000114","article-title":"Sertoli-Leydig cell tumor","volume":"264","author":"T Lantzsch","year":"2001","journal-title":"Arch Gynecol Obstet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/1097-0142(19810701)48:1<187::AID-CNCR2820480130>3.0.CO;2-1","article-title":"Sertoli-Leydig cell tumors: a clinicopathologic study of 34 cases","volume":"48","author":"L M Roth","year":"1981","journal-title":"Cancer"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00000478-198508000-00001","article-title":"Ovarian Sertoli-Leydig cell tumors. 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