{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:01:26Z","timestamp":1790370086384,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Background\u2003A small subgroup of patients treated with lower-leg cast immobilization develops venous thromboembolism (VTE).<\/jats:p><jats:p>\n            Objectives\u2003(1) Identify risk factors for VTE in patients with cast immobilization, (2) assess the effectiveness of thromboprophylaxis in low- and high-risk groups, and (3) validate the performance of the L-TRiP(cast) score.<\/jats:p><jats:p>\n            Methods\u2003Data from the POT-CAST trial were used. A total of 1,519 patients with lower-leg cast immobilization were randomized to a prophylactic dose of low-molecular-weight heparin or no treatment. Primary outcome: symptomatic VTE within 3 months. Absolute risks (ARs) were determined for low- and high-risk subgroups. For several risk factors, relative risks (RRs) for VTE were estimated with corresponding 95% confidence intervals (CIs). For validating the L-TRiP(cast) score, a discrimination and calibration analysis were performed.<\/jats:p><jats:p>\n            Results\u2003Patients with a body mass index of\u2009&gt;\u200930\u2009kg\/m2 and those with a VTE in their family history had an increased VTE risk, RR 3.8 (95% CI, 1.5\u20139.4) and RR 2.4 (95% CI, 1.0\u20135.6), respectively. Concerning injury-specific risk factors, patients with an Achilles tendon rupture or those who were surgically treated had the highest risk of VTE, AR at 8.5% (95% CI, 3.7\u201316.1) and AR 3.5% (95% CI, 1.3\u20137.5), respectively. There were no subgroups in which thromboprophylaxis was effective for prevention of symptomatic VTE. The area under the curve for the L-TRiP(cast) score was 0.69 (95% CI, 0.58\u20130.80).<\/jats:p><jats:p>\n            Conclusion\u2003Thromboprophylaxis was not effective for VTE prevention following lower-leg cast immobilization in any risk category. Low- and high-risk individuals could be identified using the L-TRiP(cast) score. The best treatment strategy for these patients is yet to be determined.<\/jats:p>","DOI":"10.1055\/s-0039-1693410","type":"journal-article","created":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T22:31:41Z","timestamp":1564353101000},"page":"1508-1516","source":"Crossref","is-referenced-by-count":19,"title":["Individualized Thromboprophylaxis in Patients with Lower-Leg Cast Immobilization\u2014A Validation and Subgroup Analysis in the POT-CAST Trial"],"prefix":"10.1055","volume":"119","author":[{"given":"Banne","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"van Adrichem","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Nelissen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[{"name":"Medical Statistics, Department of Biomedical Datascience, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne C.","family":"Cannegieter","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,7,28]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1693410.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T22:31:40Z","timestamp":1567377100000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1693410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,28]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2019,9,1]]},"published-print":{"date-parts":[[2019,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1693410","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,28]]}}}