{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:53:15Z","timestamp":1777693995429,"version":"3.51.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to examine the impact of different antibiotic treatments on necrotizing enterocolitis (NEC) outcomes.<\/jats:p><jats:p>\n          Study Design\u2003Patient outcomes, including total parenteral nutrition and hospitalization durations, abdominal surgeries, intestinal strictures, and mortality data, were analyzed and compared by various antibiotic groups and treatment durations for 160 NEC patients managed at the Women and Children's Hospital of Buffalo between 2008 and 2016.<\/jats:p><jats:p>\n          Results\u2003Fourteen different antibiotics were used for NEC, most commonly ampicillin, gentamicin, and metronidazole (AGM). Medical (vs. surgical) NEC patients more likely received AGM (37 vs. 6%, p\u2009&lt;\u20090.001). Surgical (vs. medical) NEC patients more likely received vancomycin (80 vs. 30%, p\u2009&lt;\u20090.001) and antipseudomonal agents (69 vs. 15%, p\u2009&lt;\u20090.001). For medical NEC there were no outcome differences between patients receiving only AGM versus those receiving other treatments; in patients receiving AGM, there were no outcome differences in durations of \u226410 days versus longer courses.<\/jats:p><jats:p>\n          Conclusion\u2003Antibiotic use for NEC varies substantially without definite outcome differences. Particularly with medical NEC, AGM for \u226410 days had comparable outcomes to other treatments. In light of growing concern for short and longer term adverse effects with early-life antibiotic exposure, narrow-spectrum and shorter course NEC treatment may be preferred.<\/jats:p>","DOI":"10.1055\/s-0039-1693429","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T10:29:18Z","timestamp":1564396158000},"page":"1250-1257","source":"Crossref","is-referenced-by-count":22,"title":["Antibiotic Treatments and Patient Outcomes in Necrotizing Enterocolitis"],"prefix":"10.1055","volume":"37","author":[{"given":"Catherine","family":"Murphy","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasree","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Wrotniak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Polischuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, John R. 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