{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:40:38Z","timestamp":1769150438833,"version":"3.49.0"},"reference-count":34,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n            Objective\u2003To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM).<\/jats:p><jats:p>\n            Methods\u2003A prospective case-control study that recruited healthy pregnant women (control group) (n\u2009=\u200978) and women with GDM (GDM group) (n\u2009=\u200979), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide\/cetyltrimethylammonium bromide (DTAB\/CTAB) method, and genotyping was performed by the polymerase chain reaction \u2013 restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results.<\/jats:p><jats:p>\n            Results\u2003There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60\u2009\u00b1\u20098.89\u2009ng\/mL versus 23.60\u2009\u00b1\u200910.68\u2009ng\/mL; p\u2009=\u20090.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p\u2009=\u20090.41).<\/jats:p><jats:p>\n            Conclusion\u2003There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.<\/jats:p>","DOI":"10.1055\/s-0039-1693678","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T23:44:55Z","timestamp":1564098295000},"page":"425-431","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus"],"prefix":"10.61622","volume":"41","author":[{"given":"Thais Walverde","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosiane","family":"Mattar","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Daher","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/IJWH.S26094","article-title":"Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons","volume":"3","author":"A Bener","year":"2011","journal-title":"Int J Womens Health"},{"issue":"28","key":"ref2","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1073\/pnas.1113811109","article-title":"Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy","volume":"109","author":"A V Nair","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"S 05","key":"ref3","first-page":"253","article-title":"[Insulinotherapy, maternal glycemic control and perinatal prognosis \u2013 difference between clinical and gestational diabetes]","volume":"29","author":"N A Basso","year":"2007","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"S 02","key":"ref4","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.2337\/dc07-s201","article-title":"What is gestational diabetes?","volume":"30","author":"T A Buchanan","year":"2007","journal-title":"Diabetes Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"269096","DOI":"10.1155\/2013\/269096","article-title":"New onset diabetes mellitus in living donor versus deceased donor liver transplant recipients: analysis of the UNOS\/OPTN Database","volume":"2013","author":"A D Yadav","year":"2013","journal-title":"J Transplant"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.tcam.2012.09.004","article-title":"Calcium and vitamin d metabolism, deficiency, and excess","volume":"27","author":"J Cline","year":"2012","journal-title":"Top Companion Anim Med"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1210\/jc.2007-0298","article-title":"The role of vitamin D and calcium in type 2 diabetes. 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