{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:47:50Z","timestamp":1793130470769,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            Background\u2003Studies from several countries show that self-management of vitamin K antagonist (e.g., warfarin) therapy reduce the risk of complications compared with conventional management.<\/jats:p><jats:p>\n            Objectives\u2003The aim of this study was to investigate the quality of warfarin management when patients were transferred from conventional management to self-management in Norway. In addition, quality of life (QoL) before and after 2\u2009years of warfarin self-management was investigated.<\/jats:p><jats:p>\n            Materials and Methods\u2003The study was longitudinal with a retrospective and prospective design where 126 patients on conventional management of long-term warfarin therapy underwent a 21-week training program of warfarin self-management followed by 2\u2009years of self-management. The outcomes of the study were time in therapeutic range (TTR), the variance of international normalized ratio (INR) values, extreme INR values (INR\u2009\u2264\u20091.5 and\u2009\u2265\u20095), complications, and QoL, comparing the 2-year period of the conventional management with the 2-year period with the self-management.<\/jats:p><jats:p>\n            Results\u2003The median TTR was higher during self-management compared with conventional management (78.1% vs. 65.9%, respectively, p\u2009&lt;\u20090.001). In addition, self-management resulted in lower INR variance (0.22 vs. 0.33, p\u2009&lt;\u20090.001), reduced percentage of extreme INR values (1.8% vs. 5.3%, p\u2009&lt;\u20090.001), less complications (0% vs. 5.6%), and improved QoL (p\u2009&lt;\u20090.001) compared with conventional management.<\/jats:p><jats:p>\n            Conclusion\u2003We used five different measures and found improved quality of warfarin self-management 2\u2009years after patients were transferred from the conventional management.<\/jats:p>","DOI":"10.1055\/s-0039-1693703","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T22:47:16Z","timestamp":1564699636000},"page":"1632-1641","source":"Crossref","is-referenced-by-count":14,"title":["Quality of Warfarin Therapy and Quality of Life are Improved by Self-Management for Two Years"],"prefix":"10.1055","volume":"119","author":[{"given":"Una \u00d8rvim","family":"S\u00f8lvik","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"L\u00f8kkeb\u00f8","sequence":"additional","affiliation":[{"name":"Norwegian Organization of Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Helen","family":"Kristoffersen","sequence":"additional","affiliation":[{"name":"Norwegian Organization of Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway"},{"name":"Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Brodin","sequence":"additional","affiliation":[{"name":"Division of Medicine, Department of Hematology, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Averina","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University Hospital of North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway"},{"name":"Norwegian Organization of Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway"},{"name":"Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,1]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1693703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T23:03:02Z","timestamp":1590102182000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1693703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,9,29]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1693703","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}