{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:07:18Z","timestamp":1789736838898,"version":"4.0.1"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Objective\u2003This study aimed to compare short-term respiratory outcomes of three steroids (dexamethasone, hydrocortisone, and methylprednisolone) to facilitate extubation by improving respiratory status in preterm infants.<\/jats:p><jats:p>Study Design\u2003This is a retrospective, single-center, cohort study of 98 intubated preterm infants \u2264346\/7\u2009weeks' gestation, admitted to a 64-bed, level III neonatal intensive care unit at the Women &amp; Children's Hospital of Buffalo, Buffalo, NY, between 2006 and 2012, who received a short course of low-dose steroids for lung disease after first week of life.<\/jats:p><jats:p>Results\u2003Study infants received dexamethasone (34%), hydrocortisone (44%), or methylprednisolone (22%) based on clinical team preference. By day 7 after initiation of steroids, extubation occurred in 59, 44, and 41%, respectively, in infants on dexamethasone, hydrocortisone, and methylprednisolone (p\u2009=\u20090.3). The mean respiratory severity score (RSS\u2009=\u2009fraction of inspired oxygen\u2009\u00d7\u2009mean airway pressure), a quantitative measure of respiratory status, decreased by 44% for all infants and by 59% in the dexamethasone group by day 7.<\/jats:p><jats:p>Conclusion\u2003Steroids improved short-term respiratory outcomes in all infants (RSS and extubation); by day 7, dexamethasone treatment was associated with the greatest decrease in RSS. Additional prospective, randomized trials of short-course low-dose steroids are warranted to substantiate these findings to guide clinical decision making and in evaluating differential steroid effects on long-term neurodevelopmental outcomes.<\/jats:p>","DOI":"10.1055\/s-0039-1694004","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T22:45:53Z","timestamp":1565045153000},"page":"1425-1431","source":"Crossref","is-referenced-by-count":10,"title":["Retrospective Analysis of Short-Term Respiratory Outcomes of Three Different Steroids Used in Clinical Practice in Intubated Preterm Infants"],"prefix":"10.1055","volume":"37","author":[{"given":"Sfurti","family":"Nath","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Florida College of Medicine\u2013Jacksonville, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Women & Children's Hospital of Buffalo, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UC Davis Children's Hospital, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChangXing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, State University of New York at Buffalo, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Hudak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Florida College of Medicine\u2013Jacksonville, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1542\/peds.2010-1534","article-title":"Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia","volume":"126","author":"K L Watterberg","year":"2010","journal-title":"Pediatrics"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1542\/peds.109.2.330","article-title":"Postnatal corticosteroids to treat or prevent chronic lung disease in preterm 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