{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:30:54Z","timestamp":1787830254334,"version":"build-2784847793"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venous thromboembolism (VTE) is a potentially serious complication after total knee replacement (TKR), and recent guideline recommends thromboprophylaxis for VTE after TKR. The neutrophil\u2013lymphocyte ratio (NLR) has emerged as a simple and new prognostic biomarker for several cardiovascular diseases. This study was performed to investigate the precise incidence of postoperative VTE and the role of NLR for predicting VTE in patients receiving thromboprophylaxis after TKR. We retrospectively enrolled 264 patients undergoing TKR who underwent routine screening enhanced pulmonary artery and lower extremity venography computed tomography (CT) scan within 7 postoperative days. Biochemical tests were performed within 2\u2009weeks prior to surgery, and the NLR was defined as the absolute neutrophil count in peripheral blood divided by lymphocyte count. All patients received thromboprophylaxis with enoxaparin postoperatively. Of 264 patients, 102 (38.6%) were diagnosed with deep vein thrombosis (DVT) or pulmonary embolism on CT scan. Preoperative NLR was significantly higher in patients with postoperative VTE compared with that in patients without VTE (2.57\u2009\u00b1\u20091.59 vs. 2.11\u2009\u00b1\u20091.10, p\u2009=\u20090.011). Receiver operating characteristic curve analysis showed that a preoperative NLR of 1.90 was the best cutoff value for the prediction of postoperative VTE (sensitivity 57.8%, specificity 55.6%, and area under curve 0.589). In the multivariate analysis, a preoperative NLR \u22651.90 was a sole independent predictor of postoperative VTE (odds ratio: 1.95, 95% computed tomography: 1.16\u20133.31, p\u2009=\u20090.013). The present study shows a higher incidence of VTE (38.6%) after TKR in patients receiving thromboprophylaxis than that reported in previous studies. Furthermore, preoperative NLR was significantly higher in patients with postoperative VTE, and a high preoperative NLR (\u22651.90) was an independent predictor of VTE after TKR. NLR measurement may be a simple and useful method for the prediction of VTE in patients undergoing TKR.<\/jats:p>","DOI":"10.1055\/s-0039-1694043","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T22:39:10Z","timestamp":1565303950000},"page":"171-177","source":"Crossref","is-referenced-by-count":20,"title":["Neutrophil\u2013Lymphocyte Ratio as a Predictor of Venous Thromboembolism after Total Knee Replacement"],"prefix":"10.1055","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-5485","authenticated-orcid":false,"given":"Won-Woo","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"},{"name":"Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"},{"name":"Division of Cardiology, Dongtan Sacred Heart Hospital, Dongtan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Gyun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo-Rok","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kangdong Sacred Heart Hospital, Seoul, South Korea"},{"name":"Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-7535","authenticated-orcid":false,"given":"Min-Su","family":"Hyon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, South Korea"},{"name":"Division of Cardiology, Soonchunhyang University Hospital, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1378\/chest.1412S3","article-title":"Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"G H Guyatt","year":"2012","journal-title":"Chest"},{"issue":"03","key":"ref2","first-page":"294","article-title":"Symptomatic in-hospital deep vein thrombosis and 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and venous thrombosis: results from a population-based, prospective study (the HUNT 2)","volume":"95","author":"P Quist-Paulsen","year":"2010","journal-title":"Haematologica"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1694043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:33:47Z","timestamp":1611272027000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1694043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":34,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,1,21]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1694043","relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"value":"1538-8506","type":"print"},{"value":"1938-2480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,8]]}}}