{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:19:06Z","timestamp":1769055546067,"version":"3.49.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic\u2013ischemic encephalopathy (HIE).<\/jats:p><jats:p>\n          Study Design\u2003This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO2), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2\u2009hours from the beginning of rewarming for 14\u2009hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model.<\/jats:p><jats:p>\n          Results\u2003HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO2, and MBP all decreased during WBH but showed no significant change during and after rewarming.<\/jats:p><jats:p>\n          Conclusion\u2003There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.<\/jats:p>","DOI":"10.1055\/s-0039-1694730","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T22:50:14Z","timestamp":1565823014000},"page":"037-043","source":"Crossref","is-referenced-by-count":3,"title":["Respiratory and Hemodynamic Changes in Neonates with Hypoxic\u2013Ischemic Encephalopathy during and after Whole-Body Hypothermia"],"prefix":"10.1055","volume":"38","author":[{"given":"Stephanie Rosenbloom","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MedStar Georgetown University Hospital, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Desale","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Biomedical Informatics, MedStar Health Research Institute, Hyattsville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kabir","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MedStar Georgetown University Hospital, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"issue":"15","key":"ref1","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"S Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"D Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/00003246-198711000-00001","article-title":"Hypermetabolic response after hypothermic cardiopulmonary bypass","volume":"15","author":"O Chiara","year":"1987","journal-title":"Crit Care Med"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/1053-0770(94)90195-3","article-title":"Oxygen consumption following pediatric cardiac surgery","volume":"8","author":"K Puhakka","year":"1994","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.resuscitation.2010.09.006","article-title":"The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients","volume":"81","author":"H Aslami","year":"2010","journal-title":"Resuscitation"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/apa.12476","article-title":"Respiratory function parameters in ventilated newborn infants undergoing whole body hypothermia","volume":"103","author":"T Dassios","year":"2014","journal-title":"Acta Paediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpeds.2018.01.067","article-title":"Hemodynamic changes during rewarming phase of whole-body hypothermia therapy in neonates with hypoxic-ischemic encephalopathy","volume":"197","author":"T W Wu","year":"2018","journal-title":"J Pediatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","article-title":"Mechanisms of action, physiological effects, and complications of hypothermia","volume":"37","author":"K H Polderman","year":"2009","journal-title":"Crit Care 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