{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:50:02Z","timestamp":1780465802437,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"National Center for Research Resources and the National Center for Advancing Translational Sciences"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1TR001436"],"award-info":[{"award-number":["UL1TR001436"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Abstract<\/jats:title>\n Objectives\u2003To identify whether advanced maternal age (AMA), defined as age \u226535\u2009years old, is independently associated with small for gestational age (SGA).<\/jats:p>\n Study Design\u2003This was a retrospective cohort of births from the National Vital Statistics System in the United States from 2009 to 2013. Women were categorized based on four age groups at the time of delivery: 20 to 29, 30 to 34, 35 to 39, and \u226540\u2009years old. The primary outcome of SGA\u2009<\u200910th and SGA\u2009<\u20095th percentiles was compared between the four groups using both univariable and multivariable analyses to determine whether maternal age was associated with SGA independent of parity.<\/jats:p>\n Results\u2003A total of 17,031,005 births were eligible for analysis, with 2,705,501 births to AMA women. In multivariable analyses, maternal age of 30 to 34, compared with 20 to 29, was associated with lower rates of SGA\u2009<\u200910th and <5th percentiles (adjusted odds ratio [aOR]\u2009=\u20090.95; 95% confidence interval [CI]: 0.95\u20130.96 and aOR\u2009=\u20090.97; 95% CI: 0.96\u20130.98, respectively). The AMA of 35 to 39, compared with 20 to 29, was associated with lower rates of SGA\u2009<\u200910th percentile and unchanged rates of SGA\u2009<\u20095th percentile (aOR\u2009=\u20090.97; 95% CI: 0.96\u20130.98 and aOR\u2009=\u20091; 95% CI: 0.99\u20131.01, respectively). In contrast, AMA of \u226540, compared with age 20 to 29, was associated with higher rates of both SGA\u2009<\u200910th and <5th percentiles (aOR\u2009=\u20091.06; 95% CI: 1.04\u20131.07 and aOR\u2009=\u20091.14; 95% CI: 1.12\u20131.16, respectively). A significant association was found between maternal age and parity toward the risk of SGA (p\u2009<\u20090.001). Nulliparous women \u226530\u2009years old but not multiparous women had higher rates of SGA\u2009<\u200910th and SGA\u2009<\u20095th percentiles compared with nulliparous women in the age group of 20 to 29. In contrast, both nulliparous and multiparous women age \u226540\u2009years old had an increased risk for SGA\u2009<\u20095th percentile compared with all women in the age group of 20 to 29.<\/jats:p>\n Conclusion\u2003Nulliparous women aged 30\u2009years and older have higher risk of SGA\u2009<\u200910th and SGA\u2009<\u20095th percentiles compared with nulliparous women age 20 to 29. In contrast, both nulliparous and multiparous women age 40\u2009years and older have an increased risk of SGA\u2009<\u20095th percentile compared with all women in the age group of 20 to 29.<\/jats:p>","DOI":"10.1055\/s-0039-1694775","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:46:33Z","timestamp":1566330393000},"page":"037-043","source":"Crossref","is-referenced-by-count":30,"title":["The Association between Advanced Maternal Age and Diagnosis of Small for Gestational Age"],"prefix":"10.1055","volume":"37","author":[{"given":"Anna","family":"Palatnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"De Cicco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Hibbard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard E.","family":"Egede","sequence":"additional","affiliation":[{"name":"Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,20]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1694775.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:36:18Z","timestamp":1578335778000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1694775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,6]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1694775","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]}}}