{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:19Z","timestamp":1740126799742,"version":"3.37.3"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003It is well established that women with a previous vaginal delivery have higher success rates in relation to vaginal birth after cesarean than those without. The aim of this study was to examine the effect of past mode of delivery on contractile parameters of human myometrium in vitro.<\/jats:p><jats:p>\n          Study Design\u2003Myometrial strips were excised from 64 women at cesarean delivery (CD) and recordings of spontaneous contractile activity analyzed and compared across three clinical groups: (1) women with no previous delivery (Group 1); (2) women with CD only (Group 2); and (3) women with a history of vaginal delivery and CD (Group 3).<\/jats:p><jats:p>\n          Results\u2003Myometrial samples from women in Group 3, women who had a previous vaginal delivery, had a significantly greater maximum amplitude of contractions (p\u2009&lt;\u20090.05), a greater force (mean contractile force) of contractions (p\u2009&lt;\u20090.01), and a faster rate of rise (p\u2009&lt;\u20090.01) and relaxation of contractions (p\u2009&lt;\u20090.05) than those in Groups 1 and 2.<\/jats:p><jats:p>\n          Conclusion\u2003Many of the functional parameters of human uterine contractions are altered, or enhanced, in the women who have had a previous vaginal delivery, when compared with those without. This may partly explain the clinical differences observed in labor.<\/jats:p>","DOI":"10.1055\/s-0039-1694980","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T23:46:33Z","timestamp":1566344793000},"page":"126-130","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Human Myometrial Contractility in the Third Trimester of Pregnancy in Relation to Past Mode of Delivery"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-1900","authenticated-orcid":false,"given":"Gillian A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Galway University Hospital, National University of Ireland Galway, Galway, Ireland"},{"name":"Department of Obstetrics and Gynecology, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Galway University Hospital, National University of Ireland Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis J.","family":"Crankshaw","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Galway University Hospital, National University of Ireland Galway, Galway, Ireland"},{"name":"Department of Obstetrics and Gynecology, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Galway University Hospital, National University of Ireland Galway, Galway, Ireland"},{"name":"Department of Obstetrics and Gynecology, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejogrb.2018.02.011","article-title":"Vaginal birth after caesarean section: Current status and where to from here?","volume":"224","author":"G A Ryan","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1097\/AOG.0b013e3181e459e5","article-title":"National Institutes of Health Consensus Development conference statement: vaginal birth after cesarean: new insights March 8-10, 2010","volume":"115","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"10","key":"ref6","first-page":"482","article-title":"Recent trends in vaginal birth after caesarean section","volume":"109","author":"A Brick","year":"2016","journal-title":"Ir Med 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