{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:52:21Z","timestamp":1767912741032,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Center for Research, Education, Quality, and Safety at MEDNAX, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n            Objective\u2003To define the incidence of ophthalmologic morbidities in the first 2\u2009years of life among infants diagnosed with stage 2 or higher retinopathy of prematurity (ROP).<\/jats:p><jats:p>\n            Study Design\u2003We prospectively enrolled premature infants with stage 2 or higher ROP. The infants were followed up for 2\u2009years, and we report on data collected from outpatient ophthalmology and primary care visits.<\/jats:p><jats:p>\n            Results\u2003We enrolled 323 infants who met inclusion criteria, of which 112 (35%) received treatment with laser surgery (90) or bevacizumab (22). Two-year follow-up was available for 292 (90%) of the cohort. The most common ophthalmologic conditions at follow-up were hyperopia (35%), astigmatism (30%), strabismus (21.9%), myopia (19.2%), anisometropia (12%), and amblyopia (12%). Severe ophthalmologic morbidities such as retinal detachment and cataracts were rare, but occurred in both treated and untreated infants. Overall, 22.6% of the infants were wearing glasses at 2\u2009years, including 8.5% of the untreated infants.<\/jats:p><jats:p>\n            Conclusion\u2003Patients with stage 2 or higher ROP remain at significant risk for ophthalmological morbidity through 2\u2009years of age. Infants with regression of subthreshold ROP who do not require treatment represent an underrecognized population at long-term ophthalmological risk.<\/jats:p><jats:p>\n            ClinicalTrials.gov Identifier\u2003NCT01559571.<\/jats:p>","DOI":"10.1055\/s-0039-1694983","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:12:34Z","timestamp":1567537954000},"page":"196-203","source":"Crossref","is-referenced-by-count":4,"title":["Two-Year Outcomes of Infants with Stage 2 or Higher Retinopathy of Prematurity: Results from a Large Multicenter Registry"],"prefix":"10.1055","volume":"37","author":[{"given":"Veeral N.","family":"Tolia","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Baylor University Medical Center, Dallas, Texas"},{"name":"Pediatrix Medical Group, Dallas, Texas"},{"name":"The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaashif A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group, Dallas, Texas"},{"name":"The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, Florida"},{"name":"Department of Pediatrics, Baylor College of Medicine, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Jacob","sequence":"additional","affiliation":[{"name":"Providence Alaska Medical Center, Anchorage, Alaska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Kelleher","sequence":"additional","affiliation":[{"name":"The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"McLane","sequence":"additional","affiliation":[{"name":"Greenville Health System, Greenville, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Providence Alaska Medical Center, Anchorage, Alaska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[{"name":"The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, Florida"},{"name":"Greenville Health System, Greenville, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the MEDNAX ROP Registry Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,3]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1694983.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T18:52:37Z","timestamp":1580151157000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1694983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,18]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1694983","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}