{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:21:21Z","timestamp":1770888081186,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a 7-year-old boy with tuberous sclerosis and congenital segmental lymphedema (CSL) of the left leg, as well as two aortic aneurysms. He was treated with everolimus (EVE) since the age of 14 months. His CSL regressed under treatment with EVE. His first aneurysms required operative intervention at age of 17 months. Four months afterward a new aortic aneurysm had been detected above the Dracon graft, but this one remained stable since that time. The patient didn't experience severe side effects. EVE has been well tolerated without disturbance of somatic growth or serious adverse effect.<\/jats:p>","DOI":"10.1055\/s-0039-1694985","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T22:55:22Z","timestamp":1568156122000},"page":"057-061","source":"Crossref","is-referenced-by-count":14,"title":["Congenital Lymphatic Malformation and Aortic Aneurysm in a Patient with TSC2 Mutation"],"prefix":"10.1055","volume":"51","author":[{"given":"Adelheid","family":"Wiemer-Kruel","sequence":"additional","affiliation":[{"name":"Clinic for Children and Adolescents, Epilepsy Center Kork, Tuberous Sclerosis Center, Kehl-Kork, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Mayer","sequence":"additional","affiliation":[{"name":"Clinic for Children and Adolescents, Epilepsy Center Kork, Tuberous Sclerosis Center, Kehl-Kork, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Center of the state of Bavaria, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Martinoff","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, German Heart Center of the state of Bavaria, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kriebel","sequence":"additional","affiliation":[{"name":"Department of pediatrics and pediatric cardiology, Heart Center Westpfalz, Westpfalz-Klinikum, Kaiserslautern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bissler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Tuberous Sclerosis Center of Excellence, Le Bonheur Children's Hospital, University of Tennessee, Knoxville, Tennessee, United States"},{"name":"St. Jude Children's Research Hospital, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology, Tuberous Sclerosis Clinic, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bast","sequence":"additional","affiliation":[{"name":"Clinic for Children and Adolescents, Epilepsy Center Kork, Tuberous Sclerosis Center, Kehl-Kork, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,10]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1694985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:47:23Z","timestamp":1579826843000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1694985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,23]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1694985","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]}}}