{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:32:42Z","timestamp":1757701962292,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study was aimed to determine if admission-to-delivery times vary between term nulliparous women with prelabor rupture of membranes (PROM) who initially receive oxytocin compared with buccal misoprostol for labor induction.<\/jats:p><jats:p>\n          Study Design\u2003This is a retrospective cohort of 130 term, nulliparous women with PROM and cervical dilation of \u22642\u2009cm who underwent induction of labor with intravenous oxytocin or buccal misoprostol. The primary outcome was time from admission to delivery. Linear regressions with log transformation were used to estimate the effect of induction agent on time to delivery.<\/jats:p><jats:p>\n          Results\u2003Women receiving oxytocin had faster admission-to-delivery times than women receiving misoprostol (16.9 vs. 19.9\u2009hours, p\u2009=\u20090.013). There were no significant differences in secondary outcomes between the groups. In the adjusted model, women who received misoprostol had a 22% longer time from admission to delivery (95% CI 5.0\u201342.0%) compared with women receiving oxytocin.<\/jats:p><jats:p>\n          Conclusion\u2003In term nulliparous patients with PROM, intravenous oxytocin is associated with faster admission-to-delivery times than buccal misoprostol.<\/jats:p>","DOI":"10.1055\/s-0039-1696642","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T23:17:31Z","timestamp":1567811851000},"page":"224-230","source":"Crossref","is-referenced-by-count":7,"title":["Oxytocin Compared to Buccal Misoprostol for Induction of Labor after Term Prelabor Rupture of Membranes"],"prefix":"10.1055","volume":"38","author":[{"given":"Taylor S.","family":"Freret","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7484-7920","authenticated-orcid":false,"given":"Kelly M.","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison S.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali J.","family":"Kaimal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Clapp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJM199604183341601","article-title":"Induction of labor compared with expectant management for prelabor rupture of the membranes at term. 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