{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:52:38Z","timestamp":1793213558097,"version":"4.5.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study compares high flow nasal cannula (HFNC) with nasal continuous positive airway pressure (nCPAP) within the first hour of life as the primary respiratory support in neonates of \u226432\u2009weeks of gestational age.<\/jats:p><jats:p>\n          Study Design\u2003This prospective, randomized study was conducted in infants with a gestational age of \u226432\u2009weeks who had spontaneous respiration. HFNC or nCPAP was used as a first line respiratory support after admission to intensive care unit. Primary outcome was primary treatment failure. Secondary outcomes were duration of noninvasive respiratory support and oxygen treatment, maximum FiO2 level, length of hospital stay, intubation rate, rates of respiratory distress syndrome, pneumothorax, and bronchopulmonary dysplasia. Subgroup analysis was performed for infants \u226428\u2009weeks of gestational age.<\/jats:p><jats:p>\n          Results\u2003We enrolled 107 infants, 53 in HFNC and 54 to nCPAP group. There was no difference in primary outcome between the two groups. There was no difference between the groups in aspect of secondary outcomes.<\/jats:p><jats:p>\n          Conclusion\u2003HFNC and nCPAP have no significant differences as a primary mode of respiratory support in preterm infants, in the time to wean off the devices and oxygen support, respiratory distress syndrome and bronchopulmonary dysplasia incidence, hospitalization duration, and rates of complications of prematurity.<\/jats:p>","DOI":"10.1055\/s-0039-1696673","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T22:32:20Z","timestamp":1569709940000},"page":"237-241","source":"Crossref","is-referenced-by-count":15,"title":["High Flow Nasal Cannula versus Nasal Continuous Positive Airway Pressure for Primary Respiratory Support in Preterm Infants: A Prospective Randomized Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Gamze","family":"Demirel","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binay","family":"Vatansever","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Tastekin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,28]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpeds.2008.07.021","article-title":"Observational study of humidified high-flow nasal cannula compared with nasal continuous positive airway pressure","volume":"154","author":"A L Lampland","year":"2009","journal-title":"J Pediatr"},{"issue":"S 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infant","volume":"44","author":"C Dani","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"ref14","first-page":"CD006405","article-title":"High flow nasal cannula for respiratory support in preterm infants","volume":"2","author":"D Wilkinson","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4081\/pmc.2014.88","article-title":"Comparison between two different modes of non-invasive ventilatory support in preterm newborn infants with respiratory distress syndrome mild to moderate: preliminary data","volume":"36","author":"F Ciuffini","year":"2014","journal-title":"Pediatr Med Chir"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"F315","DOI":"10.1136\/archdischild-2013-305855","article-title":"Respiratory mechanics during NCPAP and HHHFNC at equal distending pressures","volume":"99","author":"A Lavizzari","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal 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