{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:22:27Z","timestamp":1776709347625,"version":"3.51.2"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to systematically review and meta-analyze the role of lactoferrin supplementation to prevent late-onset sepsis (LOS) in preterm infants.<\/jats:p><jats:p>\n          Study Design\u2003Database search include PubMed, Web of Science, and Cochrane central for randomized clinical trial (RCTs). The Cochrane Grading of Recommendations Assessment, Development, and Evaluation methodology was used for summarizing the results.<\/jats:p><jats:p>\n          Results\u2003Ten RCTs involving 3,679 infants were included. Lactoferrin supplementation with or without probiotics decreased all LOS (relative risk [RR]: 0.56; 95% confidence interval [CI]: 0.36\u20130.86; I\n          2\u2009=\u200958%; 10 studies; 3,470 subjects; level of evidence [LOE]: low) significantly. Similarly, lactoferrin supplementation without probiotics decreased all LOS (RR: 0.43; 95% CI: 0.29\u20130.62; I\n          2\u2009=\u20090%; 8 studies; 1,209 subjects; LOE: moderate) significantly. Lactoferrin supplementation did not significantly reduce necrotizing enterocolitis (RR: 0.62; 95% CI: 0.29\u20131.33; I\n          2\u2009=\u200943%; 6 studies; 3,079 subjects; LOE: low), all-cause mortality (RR: 0.74; 95% CI: 0.36\u20131.53; I\n          2\u2009=\u200953%; 8 studies; 3,395 subjects; LOE: very low), bronchopulmonary dysplasia (RR: 1; 95% CI: 0.90\u20131.13; I\n          2\u2009=\u20090%; 4 studies; 2,570 subjects; LOE: moderate), and threshold retinopathy of prematurity eligible for surgical treatment (RR: 0.61; 95% CI: 0.25\u20131.51; I\n          2\u2009=\u200974%; 2 studies; 2,481 subjects; LOE: very low).<\/jats:p><jats:p>\n          Conclusion\u2003Low to moderate quality evidence suggests that lactoferrin supplementation reduces LOS in preterm infants. Further research is needed to improve the certainty in the evidence.<\/jats:p>","DOI":"10.1055\/s-0039-1696676","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T23:03:30Z","timestamp":1568761410000},"page":"283-290","source":"Crossref","is-referenced-by-count":20,"title":["Lactoferrin Supplementation to Prevent Late-Onset Sepsis in Preterm Infants: A Meta-Analysis"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-3694","authenticated-orcid":false,"given":"Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, King Abdullah bin Abdulaziz University Hospital, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia"},{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Bhimrao Ambedkar University, Agra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/archdischild-2014-306213","article-title":"Late-onset neonatal sepsis: recent developments","volume":"100","author":"Y Dong","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1542\/peds.2008-0377","article-title":"Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection","volume":"123","author":"D 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combining lactobacillus rhamnosus for prevention of late-onset sepsis in premature neonates","volume":"10","author":"J Z Dai","year":"2015","journal-title":"China Pract Med"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/tropej\/fmv044","article-title":"Efficacy of bovine lactoferrin supplementation in preventing late-onset sepsis in low birth weight neonates: a randomized placebo-controlled clinical trial","volume":"61","author":"G Kaur","year":"2015","journal-title":"J Trop Pediatr"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/INF.0000000000000593","article-title":"Randomized controlled trial of lactoferrin for prevention of sepsis in Peruvian neonates less than 2500\u2009g","volume":"34","author":"T J Ochoa","year":"2015","journal-title":"Pediatr Infect Dis J"},{"issue":"08","key":"ref16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/jp.2016.24","article-title":"The Lacuna trial: a double-blind randomized controlled pilot trial of lactoferrin supplementation in the very preterm infant","volume":"36","author":"K J Barrington","year":"2016","journal-title":"J Perinatol"},{"key":"ref17","first-page":"4464","article-title":"The effect of lactoferrin on low birth weight neonates during hospitalization","volume":"31","author":"Y H Liu","year":"2016","journal-title":"MCH Care China"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpeds.2016.04.084","article-title":"Randomized controlled trial of talactoferrin oral solution in preterm infants","volume":"175","author":"M P Sherman","year":"2016","journal-title":"J Pediatr"},{"key":"ref19","first-page":"1223","article-title":"Randomized control trial of lactoferrin for prevention of late onset sepsis in premature infants","volume":"32","author":"J P Tang","year":"2017","journal-title":"MCH Care 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