{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:45:06Z","timestamp":1771037106391,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The aim of the study is to obtain insights on the short and long-term safety and effectiveness of isoxsuprine hydrochloride as a tocolytic agent in the management of PTL.<\/jats:p><jats:p>\n          Study Design\u2003In this prospective, single-center, noncomparative study, patients (with preterm labor at gestational age of 24\u201337 weeks) were administered intravenous (IV) infusion of 40-mg isoxsuprine hydrochloride until uterine quiescence, followed by intramuscular (IM) injection of isoxsuprine hydrochloride 10\u2009mg\/4-hourly for first 24\u2009hours and maintained with retard 40-mg sustained release capsule (two times a day) till the time of delivery or 37 completed weeks of pregnancy.<\/jats:p><jats:p>\n          Results\u2003All patients (n\u2009=\u200950) achieved successful tocolysis in 24\u2009hours and 48\u2009hours postadministration of isoxsuprine hydrochloride (IV\/IM\/oral). Mean (\u00b1SD) gestation age at the time of delivery was 39.8\u2009\u00b1\u20092.1 weeks, with latency period of 58.5\u2009\u00b1\u200918.7 days. Pregnancy outcomes were normal in all the patients and no congenital anomaly\/fetal infection was reported. Mean (\u00b1SD) fetal birth weight was 2.7\u2009\u00b1\u20090.3\u2009kg; mean (\u00b1SD) Apgar score at 1 and 5\u2009minutes were 7.5\u2009\u00b1\u20090.6 and 9.2\u2009\u00b1\u20090.4, respectively. Maternal tachycardia and vomiting (8.0% each) were the commonly reported adverse drug reactions, which were resolved with dose adjustment.<\/jats:p><jats:p>\n          Conclusion\u2003Isoxsuprine was found to be an effective and well-tolerated tocolytic agent in arresting PTL, in turn resulting in the overall improvement in maternal and perinatal outcomes.<\/jats:p>","DOI":"10.1055\/s-0039-1696720","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T23:13:23Z","timestamp":1569366803000},"page":"291-295","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active\/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Purushottam B.","family":"Jaju","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, B.M. Patil Medical College Hospital and Research Centre, Vijayapur, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1080\/14767058.2016.1186638","article-title":"Threatened preterm labour\u2014analysis of the cytokine profile and progesterone treatment efficiency","volume":"30","author":"K Chmaj-Wierzchowska","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"435014","DOI":"10.1155\/2015\/435014","article-title":"Predicting preterm labour: current status and future prospects","volume":"2015","author":"H M Georgiou","year":"2015","journal-title":"Dis Markers"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.5455\/2320-1770.ijrcog20150409","article-title":"Comparative study of various tocolytics in preterm labor","volume":"4","author":"N Singh","year":"2015","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref4","first-page":"1238","article-title":"Comparative study of transdermal nitroglycerin patch versus isoxsuprine hydrochloride in patients with preterm labor","volume":"6","author":"S K Tambe","year":"2015","journal-title":"Int J Sci Res (Ahmedabad)"},{"key":"ref5","first-page":"48","article-title":"A prospective analysis of etiology and outcome of preterm labor","volume":"57","author":"U Singh","year":"2007","journal-title":"J Obstet Gynaecol India"},{"key":"ref6","first-page":"1039","article-title":"ACOG Committee on Practice Bulletins. 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Bishop","year":"1961","journal-title":"J Obstet Gynaecol India"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S0002-9378(16)36199-3","article-title":"The pharmacologic control of excessive uterine activity with isoxsuprine","volume":"82","author":"C H Hendricks","year":"1961","journal-title":"Am J Obstet Gynecol"},{"issue":"07","key":"ref18","first-page":"415","article-title":"Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: a systematic review of previous literature","volume":"60","author":"F L Giorgino","year":"2010","journal-title":"Arzneimittelforschung"},{"key":"ref19","first-page":"2333","article-title":"Suppression of preterm labor: a comparative study between isoxsuprine and nifedipine","volume":"3","author":"S B Nagendrappa","year":"2012","journal-title":"Int J Biol Med Res"},{"issue":"176","key":"ref20","first-page":"265","article-title":"Ritodrine and isoxsuprine in management of preterm 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