{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:09:34Z","timestamp":1782173374857,"version":"3.54.5"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objectives\u2003Lateral temporal bone malignancy remains a challenging rare disease. We report 17 years of multidisciplinary care of these tumors with univariate and multivariate analyses of key prognostic indicators for consideration in contemporary oncological management.<\/jats:p><jats:p>Design\u2003This is a retrospective cohort study.<\/jats:p><jats:p>Setting\u2003This is set at a tertiary referral center.<\/jats:p><jats:p>Participants\u2003All patients presenting with histopathologically newly diagnosed cases of temporal bone malignancy between 2000 and 2017 were included.<\/jats:p><jats:p>Main Outcome Measures\u2003The main outcome measures are disease-specific and recurrence-free survival rates.<\/jats:p><jats:p>Results\u2003In this study, 48 cases of temporal bone malignancy were diagnosed. Median age at diagnosis was 69 years (range: 5\u201388). Fourteen patients were female. Squamous cell carcinoma was the predominant malignancy in 34 cases (71%). Surgical treatment was undertaken in 37 patients. Mean length of follow-up was 32 months (range: 0.7\u2013117). Overall 5-year disease-specific survival was 52.4%, while overall 5-year recurrence-free survival was 53.5%. On univariate analysis, significantly worse survival was seen in females (p\u2009=\u20090.008), those with distant metastatic disease (p\u2009=\u20090.041), and in middle ear involvement (p\u2009=\u20090.012) with no difference for involvement of the external auditory canal (p\u2009=\u20090.98) or mastoid (p\u2009=\u20090.78). Only middle ear involvement remained significant on multivariate analysis.<\/jats:p><jats:p>Conclusion\u2003A wide variety of malignant pathology may present in the temporal bone. Recurrence-free survival is equivalent to international data; however, this figure is low. This emphasizes the need to treat these tumors appropriately with radical resection, where possible, at first presentation. Therefore, multidisciplinary surgical input is recommended. Middle ear involvement was a negative prognosticator for disease-specific and recurrence-free survivals.<\/jats:p>","DOI":"10.1055\/s-0039-1696723","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T22:53:55Z","timestamp":1567119235000},"page":"680-685","source":"Crossref","is-referenced-by-count":5,"title":["Management of Temporal Bone Malignancy in Ireland"],"prefix":"10.1055","volume":"81","author":[{"given":"Robbie S. 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Current diagnostic, therapeutic, and prognostic concepts","volume":"110","author":"M Lionello","year":"2014","journal-title":"J Surg Oncol"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/MAO.0000000000001491","article-title":"Carcinoma of the middle ear: a review of the National Cancer Database","volume":"38","author":"J A Brant","year":"2017","journal-title":"Otol Neurotol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/lary.20937","article-title":"Squamous cell carcinoma of the temporal bone","volume":"120","author":"P W Gidley","year":"2010","journal-title":"Laryngoscope"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/019459988509300202","article-title":"Facial nerve grading system","volume":"93","author":"J W House","year":"1985","journal-title":"Otolaryngology\u2013Head Neck Surg"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/lary.20999","article-title":"Outcomes following temporal bone resection","volume":"120","author":"N R Dean","year":"2010","journal-title":"Laryngoscope"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hed.20877","article-title":"Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001","volume":"30","author":"A R Madsen","year":"2008","journal-title":"Head Neck"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/00016480903390152","article-title":"The problem of nodal disease in squamous cell carcinoma of the temporal bone","volume":"130","author":"E Zanoletti","year":"2010","journal-title":"Acta Otolaryngol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.amjoto.2014.12.008","article-title":"Recurrent squamous cell carcinoma of the 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Otol"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12105-018-0908-4","article-title":"Squamous cell carcinoma of the external auditory canal and temporal bone: an update","volume":"12","author":"B M Allanson","year":"2018","journal-title":"Head Neck Pathol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5858\/arpa.2018-0415-SA","article-title":"Data set for the reporting of ear and temporal bone tumors: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting","volume":"143","author":"R Gupta","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/000348949009900909","article-title":"Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings","volume":"99","author":"M Arriaga","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"09","key":"ref20","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/hed.21883","article-title":"Predictors of survival and recurrence after temporal bone resection for cancer","volume":"34","author":"L G Morris","year":"2012","journal-title":"Head Neck"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.rpor.2015.07.004","article-title":"Temporal bone carcinoma: classical prognostic variables revisited and modern clinico-pathological evidence","volume":"21","author":"E Zanoletti","year":"2016","journal-title":"Rep Pract Oncol Radiother"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/jamaoto.2014.2606","article-title":"Middle ear mass with facial weakness. 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analysis","volume":"31","author":"T S Higgins","year":"2010","journal-title":"Otol Neurotol"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/lary.24063","article-title":"Squamous cell carcinoma of the temporal bone: outcomes of radical surgery and postoperative radiotherapy","volume":"123","author":"S C Leong","year":"2013","journal-title":"Laryngoscope"},{"issue":"04","key":"ref27","first-page":"582","article-title":"Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system","volume":"21","author":"S A Moody","year":"2000","journal-title":"Am J Otol"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1007\/s00405-014-3383-x","article-title":"Relaxin-2 expression in temporal bone carcinoma","volume":"272","author":"G Marioni","year":"2015","journal-title":"Eur Arch 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dominance in the incidence of external auditory canal squamous cell carcinoma in the Japanese population: does handedness affect carcinogenesis?","volume":"2","author":"A Tsunoda","year":"2017","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1586\/14737140.5.2.391","article-title":"Inverted papilloma involving the temporal bone and its association with squamous cell carcinoma: critical analysis of the literature","volume":"5","author":"E Gaio","year":"2005","journal-title":"Expert Rev Anticancer Ther"},{"issue":"04","key":"ref34","first-page":"1327","article-title":"Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media","volume":"150","author":"Y T Jin","year":"1997","journal-title":"Am J Pathol"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1017\/S0022215100145839","article-title":"Carcinoma of the ear: a case 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