{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:57:40Z","timestamp":1761238660450,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003To assess differences in initial symptoms, treatments, and bowel function between children with Hirschsprung's disease (HD) with or without a cognitive dysfunction (CD).<\/jats:p><jats:p>\n          Materials and Methods\u2003The study included children with HD who underwent transanal endorectal pull-through. A retrospective chart review was performed to collect data on patient characteristics, diagnosis, and treatment. Data on bowel symptoms in children older than 4 years without a colostomy were compiled during a cross-sectional, patient-reported follow-up.<\/jats:p><jats:p>\n          Results\u2003Fifty-three children with HD were included; of these, 12 (23%) had CD. The median birth weight was lower, frequency of vomiting as the presenting symptom was lower, and time until the first contact with a pediatric surgeon was higher in children with CD than in those without (3,295 vs. 3,623\u2009g, p\u2009=\u20090.013; 28 vs. 66%, p\u2009=\u20090.02; and 4 days vs. 1 day, p\u2009=\u20090.048, respectively). At follow-up, 5 (15%) of 33 children aged over 4 years had CD. More children without CD had some ability to hold back defecation and sense the urge to defecate than those with CD (p\u2009=\u20090.002 and p\u2009=\u20090.001, respectively).<\/jats:p><jats:p>\n          Conclusion\u2003HD children who have CD present with different initial symptoms, have a delay in the first consultation with a pediatric surgeon, and experience poorer bowel function outcomes than HD children without CD. Therefore, HD children with CD should receive special attention in both clinical practice and research.<\/jats:p>","DOI":"10.1055\/s-0039-1696730","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T03:44:02Z","timestamp":1567655042000},"page":"e103-e109","source":"Crossref","is-referenced-by-count":4,"title":["Children with Hirschsprung's Disease and Syndromes with Cognitive Dysfunction: Manifestations, Treatment, and Outcomes"],"prefix":"10.1055","volume":"05","author":[{"given":"Josefine","family":"Hedbys","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Hasserius","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Gran\u00e9li","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Pediatric Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Arnbj\u00f6rnsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Pediatric Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Hagelsteen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Pediatric Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-9944","authenticated-orcid":false,"given":"Pernilla","family":"Stenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Pediatric Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,4]]},"container-title":["The Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1696730.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T03:44:02Z","timestamp":1567655042000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1696730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,8,1]]},"published-print":{"date-parts":[[2019,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1696730","relation":{},"ISSN":["2378-5128","2378-5136"],"issn-type":[{"type":"print","value":"2378-5128"},{"type":"electronic","value":"2378-5136"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}