{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:38:20Z","timestamp":1776893900633,"version":"3.51.2"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003In patients undergoing coronary artery bypass grafting (CABG), wide variability in transfusion rate (7.8% to 92.8%) raises the question of the amount of unnecessary transfusions. The aim of the study was (1) to identify CABG patients at low risk of bleeding to whom transfusion treatment should be avoided and (2) to calculate the amount of possible cost savings that would be achieved by avoiding transfusion in low bleeding risk patients.<\/jats:p><jats:p>\n          Methods\u2003This retrospective observational study enrolled patients undergoing isolated elective CABG from January 2010 to January 2018. Patients were divided with respect to the presence of excessive bleeding and transfusion costs were compared between the two groups. Predictors for postoperative excessive bleeding were defined and multivariable logistic regression analysis and risk modeling were performed. The use of a model to predict patients at low risk of bleeding allowed for the estimation of transfusion cost savings assuming the patients who were found to be at low risk of bleeding should not be transfused.<\/jats:p><jats:p>\n          Results\u2003A total of 1,426 patients were enrolled in the analysis. Of those, 28.3% had excessive postoperative bleeding. The multivariate logistic regression analysis model was developed to identify\/predict patients without excessive bleeding (receiver operating characteristic curve analysis, area under the curve 72.3%, p\u2009&lt;\u20090.001). When applied to the existing database, the use of the developed model identifying patients at low risk of bleeding may result in a 39.1% reduction of transfusions. Specifically, cost savings would be 48.2% for packed red blood cells, 38.9% for fresh frozen plasma, 10.9% for platelets concentrate, and 17.9% for fibrinogen concentrate.<\/jats:p><jats:p>\n          Conclusion\u2003The clinical and economic burdens associated with unnecessary transfusions are significant. Avoiding transfusion in CABG patients found to be at low risk of bleeding may result in significant reduction of transfusion rate and transfusion-associated costs.<\/jats:p>","DOI":"10.1055\/s-0039-1697600","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T23:01:06Z","timestamp":1570834866000},"page":"621-629","source":"Crossref","is-referenced-by-count":9,"title":["Cost Analysis of Transfusion Therapy in Coronary Artery Surgery"],"prefix":"10.1055","volume":"69","author":[{"given":"Mirna","family":"Petricevic","sequence":"first","affiliation":[{"name":"University of Split School of Medicine, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mate","family":"Petricevic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijan","family":"Pasalic","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Diseases, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branka Golubic","family":"Cepulic","sequence":"additional","affiliation":[{"name":"Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Raos","sequence":"additional","affiliation":[{"name":"Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Dujmic","sequence":"additional","affiliation":[{"name":"Dora Dujmic, Lawrence University, Appleton, Wisconsin, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Kalamar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vice","family":"Mestrovic","sequence":"additional","affiliation":[{"name":"Andrija Stampar Teaching Institute of Public Health, Leadership and Management of Health Services, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrvoje","family":"Gasparovic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Vasicek","sequence":"additional","affiliation":[{"name":"Accounting Department, Faculty of Economics and 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