{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:52:20Z","timestamp":1781704340159,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"U.S. Public Health Service National Heart, Lung and Blood Institute","award":["HL109199"],"award-info":[{"award-number":["HL109199"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study was aimed to examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD\/death).<\/jats:p><jats:p>\n          Study Design\u2003Infants &lt;28 weeks' gestation who survived \u22657 days (n\u2009=\u2009423) had echocardiograms performed on day 7 and at planned intervals.<\/jats:p><jats:p>\n          Results\u2003In multivariable regression models, BPD\/death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7\u201313 days: OR (95%CI) (referent\u2009=\u2009closed or small PDA): moderate-to-large PDA exposure for &lt;7 days: 0.38 (range, 0.10\u20131.46); for 7 to 13 days\u2009=\u20092.12 (range, 1.04\u20134.32); for \u226514 days\u2009=\u20093.86 (range, 2.15\u20136.96). Once the threshold of 7 to 13 days had been reached, additional exposure (\u226514 days) did not significantly add to the increased incidence of BPD\/death: (referent exposure\u2009=\u20097\u201313 days) exposure for 14 to 27 days\u2009=\u20091.34 (range, 0.52\u20133.45); for 28 to 48 days\u2009=\u20092.34 (range, 0.88\u20136.19); for \u226549 days\u2009=\u20091.80 (range. 0.59\u20135.47). A similar relationship was found for the outcome of BPD-alone.<\/jats:p><jats:p>\n          Conclusion\u2003Infants\u2009&lt;\u200928 weeks' gestation required at least 7 to 13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD\/death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD\/death.<\/jats:p>","DOI":"10.1055\/s-0039-1697672","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T19:05:18Z","timestamp":1570734318000},"page":"216-223","source":"Crossref","is-referenced-by-count":75,"title":["Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks"],"prefix":"10.1055","volume":"37","author":[{"given":"Ronald I.","family":"Clyman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco, San Francisco, California"},{"name":"Cardiovascular Research Institute, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K.","family":"Hills","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Liebowitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Johng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,10]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1697672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T18:31:44Z","timestamp":1579372304000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1697672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,10]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,18]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1697672","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,10]]}}}