{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:19Z","timestamp":1740126799953,"version":"3.37.3"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment.<\/jats:p><jats:p>Study Design\u2003This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n\u2009=\u200929) and after (n\u2009=\u200954) a conservative approach of PDA. We compared survival, major outcomes, and neurodevelopmental impairment (NDI) at 2 years and analyzed NDI in the conservative cohort according to the duration of the PDA.<\/jats:p><jats:p>Results\u2003Conservative cohort received less medical (31.5%) and surgical treatment (7.4%) and had more days of PDA (59 days in 24\u201326 weeks and 22 days in 27\u201329 weeks; p\u2009&lt;\u20090.001) in comparison with control cohort (19 days in 24\u201326 weeks and 11 days in 27\u201329 weeks; p\u2009=\u20090.688). Mortality, survival-without-morbidity at discharge, and NDI at 2 years were similar between the two groups (p\u2009=\u20090.732). In the multivariate analysis PDA &gt;28 days was not related to worse outcomes at discharge (p\u2009=\u20090.296) or less survival-without-NDI at 2 years (p\u2009=\u20090.498).<\/jats:p><jats:p>Conclusion\u2003Until randomized trials prove the benefit of attempting to close the PDA with ibuprofen in the first week of life, conservative management may be a reasonable option.<\/jats:p>","DOI":"10.1055\/s-0039-1697674","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T23:05:18Z","timestamp":1570748718000},"page":"449-455","source":"Crossref","is-referenced-by-count":6,"title":["Neurodevelopmental Impairment at Two Years in Premature Infants with Prolonged Patency of Ductus Arteriosus after a Conservative Approach"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2737-1149","authenticated-orcid":false,"given":"Victoria","family":"Aldecoa-Bilbao","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Cl\u00ednic Barcelona, ICGON, BCNatal, Universitat de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Jes\u00fas","family":"Garc\u00eda-Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitari Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gaixa","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Centre Desenvolupament Infantil i Atenci\u00f3 Preco\u00e7, Hospital Universitari Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Clotet Caba","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Cl\u00ednic Barcelona, ICGON, BCNatal, Universitat de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Teodoro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Hospital Universitari Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Figar\u00f3 Volt\u00e0","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitari Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1542\/peds.2005-1528","article-title":"Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less","volume":"117","author":"J 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