{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T10:50:23Z","timestamp":1648551023149},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>\n Background\u2003Current recommendations for treating obesity in adolescence include a comprehensive approach (nutritional, behavioral, and exercise). Calcarea carbonica ostrearum (CCO) is a homeopathic medicine usually prescribed in obese individuals, but its effects on weight and body fat are not completely known.<\/jats:p>\n Objective\u2003The aim of this study will be to evaluate the efficacy of homeopathic CCO, in addition to a multidisciplinary intervention (diet, motivational support, and exercise program), on body fat and weight in obese adolescents.<\/jats:p>\n Methods\/Design\u2003A randomized, placebo-controlled, double-blind, parallel-group, superiority trial with 3-month study duration will be undertaken. The study will be conducted in a public research hospital in Mexico City, Hospital Ju\u00e1rez de M\u00e9xico, in the outpatient services of homeopathy and sports medicine. Eighty non-diabetic adolescents, 12 to 19 years old, who are overweight or obese, will be included. The primary outcome: change in body fat percentage at week 12. The secondary outcomes: change in mean total weight, total body mass index, fat mass index, waist\u2013hip ratio, lean muscle mass, fasting glucose, insulin, insulin resistance, lipid profile, score of Center for Epidemiologic Studies Depression Scale Revised (CESD-R) and score of Screen for Child Anxiety-Related Emotional Disorders (SCARED) at week 12. Efficacy data will be analyzed in the intention-to-treat sample. To determine the difference in the outcomes between groups at baseline and week 12, data will be analyzed using Student's t-test.<\/jats:p>\n Discussion\u2003This is the first randomized controlled trial aimed to determine the fat-reducing efficacy in obese adolescents of a homeopathic medicine, CCO, given in addition to a multidisciplinary intervention, compared with placebo plus the same intervention. It is an attempt to support scientific evidence in homeopathy for one of the most common chronic diseases, which causes high mortality due to its complications.<\/jats:p>\n ClinicalTrials.gov Identifier: NCT03945396\u2003https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03945396?term=homeopathy+for+obesity+in+Mexican+adolescents&rank=1\n <\/jats:p>","DOI":"10.1055\/s-0039-1697927","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:06Z","timestamp":1579564806000},"page":"087-096","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Homeopathy in Addition to a Multidisciplinary Intervention for Overweight or Obesity in Mexican Adolescents: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1055","volume":"109","author":[{"given":"Emma","family":"Mac\u00edas-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Servicio de Consulta Externa de Homeopat\u00eda, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara\u00ed","family":"Arellano-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina del Deporte, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Vega-Monroy","sequence":"additional","affiliation":[{"name":"Servicio de Nutrici\u00f3n, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Vera-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicio de Terapia Familiar, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Llanes-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Salud Mental Comunitaria, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"S\u00e1nchez-Navarrete","sequence":"additional","affiliation":[{"name":"Jefatura de Consulta Externa, Hospital Nacional Homeop\u00e1tico, Secretar\u00eda de Salud, Alcald\u00eda Cuauht\u00e9moc, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Enciso-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina del Deporte, Hospital Ju\u00e1rez de M\u00e9xico, Secretar\u00eda de Salud, Alcald\u00eda Gustavo A. Madero, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,20]]},"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1697927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T22:31:35Z","timestamp":1587853895000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1697927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,4,25]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1697927","relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}