{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:01:20Z","timestamp":1791424880458,"version":"4.3.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The Hans Skouby Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Cholesteatomas are benign tumors consisting of skin, and growing inside a retraction pocket in the tympanic membrane. Cholesteatomas can occupy the entirety of the middle ear, and are known for their osteolytic capabilities. Surgery is the only curative treatment for cholesteatomas.<\/jats:p><jats:p>\n          Objective\u2003To describe the risk of recurrence after first-time surgically-treated middle-ear cholesteatoma (STMEC1) on the island of Funen from 1983 to 2015.<\/jats:p><jats:p>\n          Methods\u2003Cases of STMEC1 were identified in the Danish National Hospital Register. The medical records were reviewed. Time-to-event analyses were applied. The ears were followed from STMEC1 to a secondary cholesteatoma, emigration, death, or end of follow-up.<\/jats:p><jats:p>\n          Results\u2003Records from 1,006 patients with STMEC1 were reviewed. A total of 54 patients were submitted to surgery on both ears. The total sample consisted of 1,060 ears with STMEC1; 300 were children's (&lt; 16 years) ears, and 760 were adult's ears. The total observation time was of 12,049 years.<\/jats:p><jats:p>The overall estimated proportion with recurrence 5 years after surgery was of 37% in children and of 15% in adults. The older the child was at the first surgery, the risk decreased by 7% per year. In children, canal wall up (CWU) mastoidectomy without obliteration was associated with a hazard ratio for recurrence of 1.9 (95% confidence interval [95%CI]: 1.2\u20133.0) compared with CWU with obliteration.<\/jats:p><jats:p>\n          Conclusion\u2003Compared with adults, children were had 2.6 times more risk of recurrence. Procedures performed without mastoidectomy had the lowest risk of recurrence. In children, obliteration was associated with a significantly lower risk of recurrence. However, patients were not randomized regarding the surgical approach; thus, the association between approach and risk of recurrence was likely influenced by confounding factors.<\/jats:p>","DOI":"10.1055\/s-0039-1697989","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T20:57:34Z","timestamp":1576875454000},"page":"e18-e23","source":"Crossref","is-referenced-by-count":48,"title":["Recurrence of Cholesteatoma - A Retrospective Study Including 1,006 Patients for More than 33 Years"],"prefix":"10.1055","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-8755","authenticated-orcid":false,"given":"Patrick R\u00f8nde","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Head and Neck Surgery, Zealand University Hospital, K\u00f8ge, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Nygaard","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Head and Neck Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line R.","family":"Grosfjeld","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Head and Neck Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Head and Neck Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarki D.","family":"Djurhuus","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Head and Neck Surgery, Zealand University Hospital, K\u00f8ge, Denmark"},{"name":"Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,20]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1697989.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T20:17:13Z","timestamp":1581970633000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1697989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,11,4]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1697989","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]}}}