{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:23:54Z","timestamp":1790033034767,"version":"4.0.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Historically, female patients had worse outcome undergoing heart surgery. No recent data exist on gender-specific outcome after moderate hypothermic circulatory arrest (MHCA). The aim of this large retrospective analysis was to investigate gender disparity in patients undergoing elective surgery of ascending aorta in MHCA at 24\u00b0C.<\/jats:p><jats:p>\n          Methods\u2003We conducted a retrospective review of 905 (33.3% female) cases of elective heart surgery in MHCA for ascending aortic aneurysm (90.9%) or severely calcified aorta (12.5%) between 2001 and 2015. Furthermore, 299 female and 299 male patients matched by propensity score were compared. Patients with dissection of the aorta were excluded.<\/jats:p><jats:p>\n          Results\u2003Women were older (68.4\u2009\u00b1\u20099.9 vs. 65.8\u2009\u00b1\u200911.6 years; p\u2009=\u20090.002), had higher logistic EuroSCORE I (18.4 [11.7; 29.2] vs. 12.3% [7.4; 22.6]; p\u2009&lt;\u20090.001), and significantly shorter cardiopulmonary bypass (CPB) time (132 [105; 175] vs. 150 [118; 192] minutes; p\u2009&lt;\u20090.001), while mean MHCA time was longer (15 [13; 19] vs. 14 [12; 17] minutes; p\u2009=\u20090.003). Surgical procedures were less complex in women and they were treated more frequently by isolated supracoronary ascending aorta replacement (61 vs. 54%; p\u2009=\u20090.046). Postoperatively, men showed a higher incidence of neurologic complications (7.0 vs. 3.3%; p\u2009=\u20090.03). The 30-day mortality (women 4.9% vs. men 3.9%; p\u2009=\u20090.48) did not differ significantly, likewise after statistical matching (4.7 vs. 2.3%; p\u2009=\u20090.120). Age, CPB time, and blood transfusion, but not female gender, were risk factors for mortality in multivariable regression analysis.<\/jats:p><jats:p>\n          Conclusion\u2003This study supports the hypothesis that female gender is not associated with increased short-term mortality or perioperative adverse events in elective aortic surgery in MHCA.<\/jats:p>","DOI":"10.1055\/s-0039-1698409","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T23:01:06Z","timestamp":1570834866000},"page":"314-321","source":"Crossref","is-referenced-by-count":8,"title":["Sex-Specific Outcome after Ascending Aortic Surgery in Moderate Hypothermic Circulatory Arrest"],"prefix":"10.1055","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-5759","authenticated-orcid":false,"given":"Miriam","family":"Freundt","sequence":"first","affiliation":[{"name":"Department of Hospital Medicine and Critical Care, St. Bernards Medical Center, Jonesboro, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-7164","authenticated-orcid":false,"given":"Christine","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ahmed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Panholzer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Huenges","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Puehler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assad","family":"Haneya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: a report from the American Heart Association","volume":"137","author":"E J Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/eurheartj\/ehx628","article-title":"European Society of Cardiology: cardiovascular disease statistics 2017","volume":"39","author":"A Timmis","year":"2018","journal-title":"Eur Heart J"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010","volume":"9","author":"U K 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