{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:05:43Z","timestamp":1773248743738,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Defibrotide has been approved in several geographic jurisdictions for the treatment of hepatic veno-occlusive disease\/sinusoidal obstruction syndrome (VOD\/SOS) for years. However, available data on efficacy and safety for its use in VOD are contrasting. We performed a meta-analysis to evaluate the efficacy and safety of defibrotide in the treatment of hepatic VOD\/SOS post-hematopoietic stem cell transplantation (HSCT). PubMed and Embase were searched for studies regarding the efficacy and safety of defibrotide in VOD patients. Survival rate at day\u2009+\u2009100 post-HSCT (D\u2009+\u2009100 SR), as well as the prognosis, comprising complete response (CR), adverse events including \u22651 adverse event (\u22651 AE), hemorrhage, and serious adverse events (SAEs), were pooled using a random effect model. Sixteen studies involving 3,002 participants were included. Pooled estimates for overall D\u2009+\u2009100 SR as well as rate of CR, \u22651 AE, hemorrhage, SAEs in VOD patients post-HSCT were 58% (95% CI: 54\u201362%), 57% (95% CI: 45\u201368%), 65% (95% CI: 54\u201375%), 16% (95% CI: 5\u201327%), 53% (95% CI: 51\u201355%), respectively, and were 44% (95% CI: 39\u201348%), 39% (95% CI: 28\u201350%), 88% (95% CI: 71\u2013100%), 42% (95% CI: 30\u201355%), 58% (95% CI: 52\u201364%), respectively, in severe VOD (sVOD) patients. Hemorrhage and hypotension were the most common AEs. Current evidence suggests that defibrotide improves the D\u2009+\u2009100 SR and CR in VOD\/sVOD patients following HSCT. However, the results of this review\/meta-analysis were mainly based on data from observational studies, potentially subject to selection bias. Consequently, higher quality randomized control trials and larger prospective cohort studies are warranted.<\/jats:p>","DOI":"10.1055\/s-0039-1698763","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T19:00:07Z","timestamp":1571425207000},"page":"767-777","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and Safety of Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"45","author":[{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"},{"name":"Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqian","family":"Qi","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"},{"name":"Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"},{"name":"Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"You","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgeng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China"},{"name":"Key Laboratory of Thrombosis and Haemostasis of the Ministry of Health, Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Centre of Haematology, Soochow University, Suzhou, China"},{"name":"Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,10,18]]},"container-title":["Seminars in Thrombosis and Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1698763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T19:33:54Z","timestamp":1572636834000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1698763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2019,11,1]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1698763","relation":{},"ISSN":["0094-6176","1098-9064"],"issn-type":[{"value":"0094-6176","type":"print"},{"value":"1098-9064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]}}}