{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:37:37Z","timestamp":1791632257217,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Mitomycin C is a natural antibiotic that has been used to inhibit the proliferation of fibroblasts in scar tissue.<\/jats:p><jats:p>\n          Objective\u2003To evaluate the effectiveness and safety of topical Mitomycin C as an adjuvant in the endoscopic treatment of laryngotracheal stenoses.<\/jats:p><jats:p>\n          Data synthesis\u2003A systematic review of experimental or observational studies that have evaluated the treatment of laryngotracheal stenoses with the use of topical Mitomycin C was performed. Databases researched: LILACS, PubMed, Embase, Cochrane and Web of Science. Outcomes: resolution (symptom-free time\u2009\u2265\u2009one year), number of procedures required, and complications resulting from the procedure. A total of 15 studies (involving 387 patients) were selected. Mitomycin C was administered to every patient in 11 studies, and in 4 other studies, the patients were separated into 2 groups, 1 receiving mitomycin C, and the other not. The resolution of the stenosis evaluated in 12 studies in which the patients received mitomycin C was of 69% (95% confidence interval [95%CI]: 61\u201376%; I2\u2009=\u200917.3%). A total of 52% of the patients (95%CI: 39\u201364%, 11 studies; I2\u2009=\u200964.7%) were submitted to a single endoscopic procedure, and 48% (95%CI: 36\u201361%, 11 studies; I2\u2009=\u200964.7%) were submitted to more than 1 procedure. Complications (mediastinal and subcutaneous emphysema, dysphonia, laceration or vocal fold paralysis and acute light obstruction) were reported in 9% of the patients (95%CI: 3\u201318%, 9 studies; I2\u2009=\u200979.8%).<\/jats:p><jats:p>\n          Conclusions\u2003The evidence suggests that mitomycin C is an effective and safe option in the endoscopic treatment of laryngotracheal stenosis.<\/jats:p>","DOI":"10.1055\/s-0039-1700582","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T20:57:34Z","timestamp":1576875454000},"page":"e112-e124","source":"Crossref","is-referenced-by-count":21,"title":["Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis"],"prefix":"10.1055","volume":"24","author":[{"given":"Thereza L. O.","family":"Queiroga","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculdade de Ci\u00eancias M\u00e9dicas e Biol\u00f3gicas de Botucatu, Universidade Estadual Paulista, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele C.","family":"Cataneo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculdade de Ci\u00eancias M\u00e9dicas e Biol\u00f3gicas de Botucatu, Universidade Estadual Paulista, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-1962","authenticated-orcid":false,"given":"Regina H. G.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculdade de Ci\u00eancias M\u00e9dicas e Biol\u00f3gicas de Botucatu, Universidade Estadual Paulista, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarcisio A.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculdade de Ci\u00eancias M\u00e9dicas e Biol\u00f3gicas de Botucatu, Universidade Estadual Paulista, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio J. M.","family":"Cataneo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculdade de Ci\u00eancias M\u00e9dicas e Biol\u00f3gicas de Botucatu, Universidade Estadual Paulista, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,20]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1700582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T03:40:05Z","timestamp":1579059605000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1700582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,11,4]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1700582","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]}}}