{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:15:51Z","timestamp":1793643351996,"version":"4.5.1"},"reference-count":27,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Estimate the prevalence of human herpesvirus type 1 HSV-1 DNA in placental samples, its incidence in umbilical cord blood of newborns and the associated risk factors.<\/jats:p><jats:p>\n          Methods\u2003Placental biopsies and umbilical cord blood were analyzed, totaling 480 samples, from asymptomatic parturients and their newborns at a University Hospital. Nested polymerase chain reaction (PCR) and gene sequencing were used to identify the virus; odds ratio (OR) and relative risk (RR) were performed to compare risk factors associated with this condition.<\/jats:p><jats:p>\n          Results\u2003The prevalence of HSV-1 DNA in placental samples was 37.5%, and the incidence in cord blood was 27.5%. Hematogenous transplacental route was identified in 61.4% from HSV-1+ samples of umbilical cord blood paired with the placental tissue. No evidence of the virus was observed in the remaining 38.6% of placental tissues, suggesting an ascendant infection from the genital tract, without replication in the placental tissue, resulting in intra-amniotic infection and vertical transmission, seen by the virus in the cord blood. The lack of condom use increased the risk of finding HSV-1 in the placenta and umbilical cord blood.<\/jats:p><jats:p>\n          Conclusion\u2003The occurrence of HSV-1 DNA in the placenta and in cord blood found suggests vertical transmission from asymptomatic pregnant women to the fetus.<\/jats:p>","DOI":"10.1055\/s-0039-1700794","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T23:33:16Z","timestamp":1582846396000},"page":"005-011","source":"Crossref","is-referenced-by-count":11,"title":["High Incidence of Herpes Simplex Virus-1 in Cord Blood and Placenta Infection of Women in Southern Brazil"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-090X","authenticated-orcid":false,"given":"Emiliana Claro","family":"Avila","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-6798","authenticated-orcid":false,"given":"Fabiana","family":"Finger-Jardim","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-6355","authenticated-orcid":false,"given":"Carla Vitola","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Center for Obstetrics and Gynecology, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-9876","authenticated-orcid":false,"given":"Vanusa Pousada","family":"da Hora","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-1152","authenticated-orcid":false,"given":"Marcelo Alves","family":"Soares","sequence":"additional","affiliation":[{"name":"Oncovirology Program, Instituto Nacional do C\u00e2ncer (INCA), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-0642","authenticated-orcid":false,"given":"Ana Maria Barral de","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1128\/CMR.00043-15","article-title":"Current concepts for genital herpes 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