{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:12:09Z","timestamp":1792062729712,"version":"4.4.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective\u2003The current study initiated to address the effect of glucose-6-phosphate dehydrogenase (G6PD) deficiency on the pathogenesis and the severity of neonatal hyperbilirubinemia (NHB).<\/jats:p>\n                  <jats:p>Study Design\u2003A total of 100 newborns with moderate to severe indirect hyperbilirubinemia and 50 normal neonates without hyperbilirubinemia had been enrolled in the current case\u2013control study. All enrolled neonates had been tested for ABO and Rh(D) blood grouping, Total serum bilirubin measurement, complete blood count, morphology, reticulocyte counts, direct Coombs' test, and G6PD enzyme assay.<\/jats:p>\n                  <jats:p>Results\u2003From all enrolled hyperbilirubinemic neonates, 16% were G6PD deficient and this displays a statistically significant difference in comparison to controls (only 6% were G6PD deficient). Also, significant difference was found in the level of serum indirect bilirubin among G6PD-deficient neonate in comparison to G6PD nondeficient neonates which had contributed significantly to the difference in the duration of phototherapy and hospitalization among deficient neonate. Despite this, no significant difference found in the onset of presentation, reticulocytes count, and age of neonates between the two groups (G6PD-deficient and G6PD nondeficient neonates).<\/jats:p>\n                  <jats:p>Conclusion\u2003The current study augments the etiological role of G6PD in the causation and severity of NHB in the region; however, in the absence of significant difference in the reticulocytes and the hemoglobin level, the underlying mechanism cannot be backed to the excess hemolysis alone.<\/jats:p>","DOI":"10.1055\/s-0039-1700854","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T18:58:26Z","timestamp":1574103506000},"page":"575-580","source":"Crossref","is-referenced-by-count":11,"title":["G6PD Deficiency Prevalence as a Cause of Neonatal Jaundice in a Neonatal Ward in Dohuk, Iraq"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-321X","authenticated-orcid":false,"given":"Adil Abozaid","family":"Eissa","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, University of Duhok, Duhok, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijar Ali","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Hematology, Duhok Directorate of Health, Duhok, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan Anwar","family":"Al-Doski","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, University of Duhok, Duhok, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","year":"2004","journal-title":"Pediatrics"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0095-5108(18)30571-2","article-title":"Does hyperbilirubinemia damage the brain of healthy full-term infants?","volume":"17","author":"T B Newman","year":"1990","journal-title":"Clin Perinatol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/pch\/12.5.401","article-title":"Guidelines for detection, management and prevention of hyperbilirubinemia in term and late preterm newborn infants (35 or more weeks' gestation) - 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Iraq","volume":"12","author":"B M Al-Musawi","year":"2012","journal-title":"BMC Blood Disord"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12288-014-0368-2","article-title":"Molecular characterization of G6PD deficient variants in Nineveh province, northwestern Iraq","volume":"31","author":"M A Kashmoola","year":"2015","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.26719\/2003.9.1-2.45","article-title":"Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra","volume":"9","author":"M K Hassan","year":"2003","journal-title":"East Mediterr Health J"},{"issue":"05","key":"ref11","first-page":"558","article-title":"Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures, and treatments: a narrative review article","volume":"45","author":"S Ullah","year":"2016","journal-title":"Iran J Public Health"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1542\/peds.107.5.1075","article-title":"Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia","volume":"107","author":"M C Harris","year":"2001","journal-title":"Pediatrics"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/(SICI)1098-1004(199910)14:4<352::AID-HUMU14>3.0.CO;2-G","article-title":"Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Chinese","volume":"14","author":"O Ainoon","year":"1999","journal-title":"Hum Mutat"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12098-008-0024-7","article-title":"Jaundice in the newborns","volume":"75","author":"S Mishra","year":"2008","journal-title":"Indian J Pediatr"},{"issue":"02","key":"ref15","first-page":"1","article-title":"Mutation analyses of bilirubin UGT1A1 gene in neonatal that associated with hyperbilirubinemia in Al-Najaf province","volume":"6","author":"R Al-Hussaini","year":"2014","journal-title":"Magazine of Al-Kufa University for Biology"},{"issue":"03","key":"ref16","first-page":"215","article-title":"Neonatal jaundice: its prevalence in Chinese babies and associating factors","volume":"22","author":"T F Fok","year":"1986","journal-title":"Aust Paediatr J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.5455\/ijmsph.2015.20112014125","article-title":"A study of glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinemia","volume":"4","author":"H Patel","year":"2015","journal-title":"Int J Med Sci Public Health"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.2007-0967","article-title":"Outcomes in a population of healthy term and near-term infants with serum bilirubin levels of >or=325 micromol\/L (>or=19\u2009mg\/dL) who were born in Nova Scotia, Canada, between 1994 and 2000","volume":"122","author":"K A Jangaard","year":"2008","journal-title":"Pediatrics"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archpedi.1990.02150270114039","article-title":"Laboratory evaluation of jaundice in newborns. Frequency, cost, and yield","volume":"144","author":"T B Newman","year":"1990","journal-title":"Am J Dis Child"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3889\/oamjms.2015.129","article-title":"Evaluation of neonatal hemolytic jaundice: clinical and laboratory parameters","volume":"3","author":"A P Cherepnalkovski","year":"2015","journal-title":"Open Access Maced J Med Sci"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1891\/0730-0832.26.5.277","article-title":"Caput succedaneum and cephalohematoma: the cs that leave bumps on the head","volume":"26","author":"L Nicholson","year":"2007","journal-title":"Neonatal Netw"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1479-828X.1987.tb00988.x","article-title":"Cephalhaematoma: a 10-year review","volume":"27","author":"K E Thacker","year":"1987","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jpeds.2010.05.024","article-title":"Hemolysis and hyperbilirubinemia in antiglobulin positive, direct ABO blood group heterospecific neonates","volume":"157","author":"M Kaplan","year":"2010","journal-title":"J Pediatr"},{"issue":"01","key":"ref24","first-page":"1","article-title":"ABO and Rh blood groups polymorphism among the Kurds of Duhok, Iraq","volume":"8","author":"A Eissa","year":"2014","journal-title":"Duhok Med J"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta13100","article-title":"Routine antenatal anti-D prophylaxis for RhD-negative women: a systematic review and economic evaluation","volume":"13","author":"H Pilgrim","year":"2009","journal-title":"Health Technol Assess"},{"issue":"09","key":"ref26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/aogs.12193","article-title":"Consequences of being Rhesus D immunized during pregnancy and how to optimize new prevention strategies","volume":"92","author":"E Tiblad","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"03","key":"ref27","first-page":"223","article-title":"Relative frequency of glucose-6-phosphate dehydrogenase deficiency in jaundiced newborn infants in the metropolitan area of Monterrey, Nuevo Le\u00f3n [in Spanish]","volume":"21","author":"G Gonz\u00e1lez-Quiroga","year":"1990","journal-title":"Arch Invest Med (Mex)"},{"issue":"11","key":"ref28","first-page":"524","article-title":"Glucose-6-phosphate dehydrogenase et neonatal jaundice [in French]","volume":"30","author":"C Badens","year":"2001","journal-title":"Presse Med"},{"issue":"S 02","key":"ref29","first-page":"70","article-title":"Mass newborn screening for glucose-6-phosphate dehydrogenase deficiency in Singapore","volume":"30","author":"R Joseph","year":"1999","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"06","key":"ref30","doi-asserted-by":"crossref","first-page":"e1568","DOI":"10.1542\/peds.2013-3500","article-title":"Safety and efficacy of filtered sunlight in treatment of jaundice in African neonates","volume":"133","author":"T M Slusher","year":"2014","journal-title":"Pediatrics"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/02724936.1992.11747604","article-title":"Screening for glucose-6-phosphate dehydrogenase deficiency can prevent severe neonatal jaundice","volume":"12","author":"A A Mallouh","year":"1992","journal-title":"Ann Trop Paediatr"},{"issue":"07","key":"ref32","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/00007611-199507000-00019","article-title":"Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn","volume":"88","author":"E C Washington","year":"1995","journal-title":"South Med J"},{"issue":"08","key":"ref33","first-page":"663","article-title":"Molecular characterization of severe G6PD deficiency in hyperbilirubinemic neonates in Karbala: Iraq","volume":"2","author":"F Al-Touma","year":"2009","journal-title":"Karbala J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/02724936.1987.11748490","article-title":"Neonatal jaundice and G6PD deficiency in Basra","volume":"7","author":"L Al-Naamah","year":"1987","journal-title":"Ann Trop Paediatr"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1086\/513901","article-title":"Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28","volume":"61","author":"E Pegoraro","year":"1997","journal-title":"Am J Hum Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1542\/peds.104.1.68","article-title":"Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes","volume":"104","author":"M Kaplan","year":"1999","journal-title":"Pediatrics"},{"issue":"05","key":"ref37","first-page":"424","article-title":"Evaluation of neonatal indirect hyperbilirubinaemia at Zanjan Province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency","volume":"48","author":"A Koosha","year":"2007","journal-title":"Singapore Med J"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/tropej\/fmi042","article-title":"Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia","volume":"52","author":"E Atay","year":"2006","journal-title":"J Trop Pediatr"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1542\/peds.90.3.401","article-title":"Neonatal hyperbilirubinemia associated with glucose-6-phosphate dehydrogenase deficiency in Sephardic-Jewish neonates: incidence, severity, and the effect of phototherapy","volume":"90","author":"M 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