{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:21:58Z","timestamp":1782375718500,"version":"3.54.5"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Retinopathy of prematurity (ROP) is the leading preventable cause of blindness in children worldwide. Major eye and visual problems are strongly linked to ROP requiring treatment. Objectives of the study are to: (1) evaluate the trends and regional differences in the proportion of treated ROP, (2) describe risk factors, and (3) examine if treated ROP predicts mortality.<\/jats:p><jats:p>\n          Study Design\u2003Retrospective data analysis was conducted using the Kids' Inpatient Database from 1997 to 2012. ROP was categorized into treated ROP (requiring laser photocoagulation or surgical intervention) and nontreated ROP. Bivariate and multivariate logistic regression analyses were performed.<\/jats:p><jats:p>\n          Results\u2003Out of 21,955,949 infants\u2009\u2264\u200912 months old, we identified 70,541 cases of ROP and 7,167 (10.2%) were treated. Over time, the proportion of treated ROP decreased (p\u2009=\u2009&lt;\u20090.001). While extremely low birth weight infants cared for in the Midwest was associated with treated ROP (adjusted odds ratio [aOR]\u2009=\u200929.05; 95% confidence interval [CI]: 10.64\u201379.34), black race (aOR\u2009=\u20090.57; 95% CI: 0.51\u20130.64) care for in the birth hospital (aOR\u2009=\u20090.44; 95% CI: 0.41\u20130.48) was protective. Treated ROP was not associated with mortality.<\/jats:p><jats:p>\n          Conclusion\u2003The proportion of ROP that is surgically treated has decreased in the United States; however, there is variability among the different regions. Demographics and clinical practice may have contributed for this variability.<\/jats:p>","DOI":"10.1055\/s-0039-1700855","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T23:58:26Z","timestamp":1574121506000},"page":"581-589","source":"Crossref","is-referenced-by-count":4,"title":["Proportion of Retinopathy of Prematurity That Was Treated across Regions in the United States"],"prefix":"10.1055","volume":"38","author":[{"given":"Rowena G.","family":"Cayabyab","sequence":"additional","affiliation":[{"name":"Division of Neonatalogy, Department of Pediatrics, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Song","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Institute, Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California"},{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Division of Neonatalogy, Department of Pediatrics, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Friedlich","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Institute, Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Lakshmanan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California"},{"name":"Leonard D. Schaeffer Center for Health Policy and Economics, School of Pharmacy, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaapos.2012.09.004","article-title":"An update on progress and the changing epidemiology of causes of childhood blindness worldwide","volume":"16","author":"L Kong","year":"2012","journal-title":"J AAPOS"},{"issue":"S 01","key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"H Blencowe","year":"2013","journal-title":"Pediatr Res"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MOP.0b013e3283423f35","article-title":"Current update on retinopathy of prematurity: screening and treatment","volume":"23","author":"J Chen","year":"2011","journal-title":"Curr Opin Pediatr"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/sj.jp.7211067","article-title":"Retinopathy of prematurity and pulse oximetry: a national survey of recent practices","volume":"24","author":"C G Anderson","year":"2004","journal-title":"J Perinatol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"F106","DOI":"10.1136\/fn.84.2.F106","article-title":"Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation","volume":"84","author":"W Tin","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1542\/peds.111.2.339","article-title":"Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?","volume":"111","author":"L C Chow","year":"2003","journal-title":"Pediatrics"},{"issue":"21","key":"ref7","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa0911781","article-title":"Target ranges of oxygen saturation in extremely preterm infants","volume":"362","author":"W A Carlo","year":"2010","journal-title":"N Engl J Med"},{"key":"ref8","first-page":"2094","article-title":"The BOOST II United Kingdom, Australia, and New Zealand Collaborative Groups. 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