{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:24:12Z","timestamp":1762899852780,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, The University of Texas McGovern Medical School at Houston"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Preterm delivery following fetoscopic laser surgery (FLS) of twin\u2013twin transfusion syndrome (TTTS) is associated with severe perinatal morbidity and mortality. The role of steroid hormones in amniotic fluid (AF) after FLS remains unknown.<\/jats:p><jats:p>\n          Study Design\u2003A prospective cohort study of consecutive case series of FLS for TTTS was performed from April 2012 to February 2017. Cases were divided into early (\u226427 weeks) spontaneous preterm delivery (ED) and late delivery (LD; \u226534 weeks) following FLS and compared. AF supernatants were assessed for protein, estradiol, progesterone and cortisol levels (using the ELISA kit), and normalized to total protein levels to adjust for dilution.<\/jats:p><jats:p>\n          Results\u2003A total of 294 consecutive cases of FLS for TTTS in monochorionic\u2013diamniotic twins were performed during the study period. AF was available in 44 ED patients and 50 LD patients. On logistic regression, ED was associated with higher normalized progesterone levels (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.12\u20131.41), lower normalized cortisol (OR: 0.78; 95% CI: 0.64\u20130.96), and higher estradiol levels (OR: 1.3; 95% CI: 1.03\u20131.63).<\/jats:p><jats:p>\n          Conclusion\u2003Elevated AF normalized progesterone and estradiol, and lower normalized cortisol levels were associated with ED. This novel finding requires further exploration to establish the molecular mechanism operational in pregnancies complicated by TTTS to potentially prevent early preterm birth after fetal surgery.<\/jats:p>","DOI":"10.1055\/s-0039-1700862","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:38:28Z","timestamp":1577839108000},"page":"562-569","source":"Crossref","is-referenced-by-count":2,"title":["Steroid Hormone Levels in Recipient Amniotic Fluid in Twin\u2013Twin Transfusion Syndrome and Their Association with Preterm Delivery"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-7481","authenticated-orcid":false,"given":"Mallory","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovepreet K.","family":"Mann","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong H.","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric P.","family":"Bergh","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopali","family":"Donepudi","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Moise","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"Macpherson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The George Washington University Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Thom","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The George Washington University Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Mesiano","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesha","family":"Papanna","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, UTHealth, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,31]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1700862.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T22:57:14Z","timestamp":1587769034000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1700862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,31]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,4,24]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1700862","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published":{"date-parts":[[2019,12,31]]}}}