{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:02:53Z","timestamp":1782241373200,"version":"3.54.5"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003We herein aimed for analysis of influence of mitral annular calcification (MAC) and mitral stenosis (MS) on outcomes in transcatheter aortic valve implantation (TAVI).<\/jats:p><jats:p>\n          Methods\u2003Between 11\/2009 and 06\/2017, 1,058 patients underwent TAVI in the presence of concomitant MAC or MS at our center. Subgroups were built and multivariate logistic regression, COX regression, Kaplan\u2013Meier survival analyses, and receiver operating characteristics method were performed.<\/jats:p><jats:p>\n          Results\u2003Thirty-day mortality was 7.5% (79\/1,058) with highest mortality in patients severe MS (MAC: 3.4% vs. mild MS: 5.9% vs. moderate MS: 15.0% vs. severe MS: 72.7%; p\u2009&lt;\u20090.001). Moderate-to-severe MS (odds ratio [OR]: 7.75, confidence interval [CI]: 3.94\u201316.26, p\u2009&lt;\u20090.001), impaired left ventricular ejection fraction (OR: 1.38, CI: 1.10\u20131.72, p\u2009&lt;\u20090.01), and coronary artery disease (OR: 1.36, CI: 1.11\u20131.67, p\u2009&lt;\u20090.01) were predictive of 30-day survival. Left ventricular systolic\/end-diastolic pressure drop of &lt;59.5\u2009mm Hg \/ &lt;19.5\u2009mm Hg was associated with increased mortality.<\/jats:p><jats:p>\n          Conclusions\u2003TAVI in the presence of MAC and mild MS is associated with acceptable acute outcomes but should be considered high-risk procedures in patients with moderate and especially those with severe MS. Our results suggest adverse hemodynamics after TAVI with concomitant MS, which may be caused by underfilling of the left ventricle leading to low-cardiac output.<\/jats:p>","DOI":"10.1055\/s-0039-1700966","type":"journal-article","created":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T23:33:10Z","timestamp":1583105590000},"page":"428-436","source":"Crossref","is-referenced-by-count":11,"title":["TAVI in Patients with Mitral Annular Calcification and\/or Mitral Stenosis"],"prefix":"10.1055","volume":"69","author":[{"given":"Andreas","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"Sarwari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Schofer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Schneeberger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schoen","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"issue":"36","key":"ref1","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"H Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC Focused Update of the 2014 AHA\/ACC Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"R A Nishimura","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"ref3","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"M B Leon","year":"2016","journal-title":"N Engl J Med"},{"issue":"14","key":"ref4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"SURTAVI Investigators. 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