{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:29:17Z","timestamp":1767652157159},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Sichuan Science and Technology Program","award":["2018SZ0145"],"award-info":[{"award-number":["2018SZ0145"]}]},{"name":"Sichuan Science and Technology Program","award":["2018SZYZF0006"],"award-info":[{"award-number":["2018SZYZF0006"]}]},{"name":"Program of Sichuan Health Commission","award":["17PJ128"],"award-info":[{"award-number":["17PJ128"]}]},{"name":"2016 Innovation Fund Project of Guangan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To improve the long-term outcomes of high tibial osteotomy (HTO) for gonarthritis, many cartilage repair procedures appeared, but their effects were controversial. To evaluate the efficacy of cartilage repair procedures during HTO for gonarthritis, we performed this update meta-analysis. We performed the system retrieval for clinical trials using various databases and then pooled the outcomes of the included studies. Fifteen studies were involved. The pooled results indicated that there were no significant differences in Kellgren and Lawrence (KL) scale (mean difference [MD]\u2009=\u20090.02, 95% confidence interval [CI]\u2009=\u2009\u22120.01 to 0.06, p\u2009=\u20090.24), the femorotibial angle (MD\u2009=\u20090.06, 95% CI\u2009=\u2009\u22120.04 to 0.16, p\u2009=\u20090.22), and magnetic resonance imaging (MRI) outcomes (MD\u2009=\u200912.53, 95% CI\u2009=\u2009\u22122.26 to 27.32, p\u2009=\u20090.10) of patients in experimental group than control. The subgroup analysis showed that the clinical outcomes of abrasion arthroplasty (AA) were worse than control group (standardized mean difference [SMD] \u22122.65, 95% CI\u2009=\u2009\u22123.67 to \u22121.63, p\u2009&lt;\u20090.001), while mesenchymal stem cells (MSCs) injection improved the clinical outcomes (SMD\u2009=\u20092.37, 95% CI\u2009=\u20091.25\u20133.50, p\u2009&lt;\u20090.001). There were significant differences between the two groups in arthroscopic (SMD\u2009=\u20091.38, 95% CI\u2009=\u20090.82\u20131.94, p\u2009&lt;\u20090.001) and histologic results (relative risk [RR]\u2009=\u20091.77, 95% CI\u2009=\u20091.36\u20132.29, p\u2009&lt;\u20090.001). The pain relief (MD\u2009=\u20090.17, 95% CI\u2009=\u2009\u22123.26 to 3.61, p\u2009=\u20090.92) and operative complications (RR\u2009=\u20091.42, 95% CI\u2009=\u20090.83\u20132.42; p\u2009=\u20090.19) of the two groups had no significant differences. Our analysis supports that concurrent cartilage repair procedures might improve arthroscopic and histologic outcomes, but they have no beneficial effect on clinical outcomes, radiograph, MRI, and pain relief. The concurrent procedures do not increase the risk of operative complication. Furthermore, MSC has some beneficial effects on clinical outcomes, while AA might play an opposite role.<\/jats:p>","DOI":"10.1055\/s-0039-1700978","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T23:40:23Z","timestamp":1579304423000},"page":"952-961","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of High Tibial Osteotomy with or without Other Procedures for Medial Compartment Osteoarthritis of Knee: An Update Meta-Analysis"],"prefix":"10.1055","volume":"34","author":[{"given":"Ru-Zhan","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Qiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery, Weifang People's Hospital, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Zhi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Weifang People's Hospital, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Dong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Weifang People's Hospital, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Department of Orthopaedics, The People's Hospital of Guang'an City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/jars.2002.30488","article-title":"A comparison of the healing potential of fibrillated cartilage versus eburnated bone in osteoarthritic knees after high tibial osteotomy: an arthroscopic study with 1-year follow-up","volume":"18","author":"S Wakabayashi","year":"2002","journal-title":"Arthroscopy"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joca.2005.08.013","article-title":"Factors that influence high tibial osteotomy results in patients with medial gonarthritis: a score to predict the results","volume":"14","author":"G Spahn","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"13","key":"ref3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijsu.2018.10.045","article-title":"Is opening-wedge high tibial osteotomy superior to closing-wedge high tibial osteotomy in treatment of unicompartmental osteoarthritis? A meta-analysis of randomized controlled trials","volume":"60","author":"Z Wang","year":"2018","journal-title":"Int J Surg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s001670050117","article-title":"Articular cartilage regeneration of the knee joint after proximal tibial valgus osteotomy: a prospective study of different intra- and extra-articular operative techniques","volume":"7","author":"W Schultz","year":"1999","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.arthro.2014.05.036","article-title":"Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study","volume":"30","author":"Y G Koh","year":"2014","journal-title":"Arthroscopy"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1177\/0363546518785973","article-title":"Comparative matched-pair analysis of open-wedge high tibial osteotomy with versus without an injection of adipose-derived mesenchymal stem cells for Varus knee osteoarthritis: clinical and second-look arthroscopic results","volume":"46","author":"Y S Kim","year":"2018","journal-title":"Am J Sports Med"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.arthro.2013.10.008","article-title":"Second-look arthroscopic assessment of cartilage regeneration after medial opening-wedge high tibial osteotomy","volume":"30","author":"W H Jung","year":"2014","journal-title":"Arthroscopy"},{"issue":"03","key":"ref8","first-page":"272","article-title":"Cartilage regeneration after high tibial osteotomy. 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Biopsies after 2 years in 19 cases","volume":"63","author":"H Bergenudd","year":"1992","journal-title":"Acta Orthop Scand"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0749-8063(89)90086-8","article-title":"The arthroscopic treatment of unicompartmental gonarthrosis: a five-year follow-up study of abrasion arthroplasty plus arthroscopic debridement and arthroscopic debridement alone","volume":"5","author":"J M Bert","year":"1989","journal-title":"Arthroscopy"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1007\/s00167-012-1925-6","article-title":"Microfracture for knee chondral defects: a survey of surgical practice among Canadian orthopedic surgeons","volume":"20","author":"J Theodoropoulos","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1700978.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T22:33:12Z","timestamp":1626906792000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1700978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":33,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2021,7,21]]},"published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1700978","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"value":"1538-8506","type":"print"},{"value":"1938-2480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]}}}