{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:06:09Z","timestamp":1789610769097,"version":"build-2803163510"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003To assess the incidence and severity of acute kidney injury (AKI) and evaluate risk factors that predict AKI in asphyxiated infants receiving therapeutic hypothermia.<\/jats:p><jats:p>Study Design\u2003Infants \u226536 weeks' gestation diagnosed with moderate-to-severe perinatal asphyxia and received therapeutic hypothermia were reviewed retrospectively (n\u2009=\u2009166). Modified Acute Kidney Injury Network criteria were used to diagnose AKI. The results of infants with AKI were compared with the infants who did not develop AKI.<\/jats:p><jats:p>Results\u2003AKI developed in 49 (29.5%) infants, of whom 22 had stage I, 13 had stage II, and 14 had stage III AKI. The overall mortality rate was 15.7% and was significantly higher in infants with AKI when compared with infants without AKI (41 vs. 5%; p\u2009&lt;\u20090.001). Asystole at birth (p\u2009=\u20090.044), placental abruption (p\u2009=\u20090.041), outborn status (p\u2009=\u20090.041), need for vasopressor support (p\u2009=\u20090.031), increased bleeding tendency (p\u2009=\u20090.031), initial lactate level (p\u2009=\u20090.015), and 12-hour lactate level (p\u2009=\u20090.029) were independent risk factors for the development of AKI. Receiver operating characteristic curve analysis demonstrated a good predictive value for initial lactate level (&gt;15\u2009mmol\/L), with 69% sensitivity (95% CI: 55\u201382) and 82% specificity (95% CI: 74\u201389), and for 12-hour lactate level (&gt;6\u2009mmol\/L), with 83.7% sensitivity (95% CI: 70\u201393) and 73.5% specificity (95% CI: 64.5\u201381), to predict AKI.<\/jats:p><jats:p>Conclusion\u2003AKI is still a common complication of perinatal asphyxia despite treatment with therapeutic hypothermia. Identification of risk factors associated with the development of AKI in asphyxiated infants would be potentially beneficial to reduce morbidity and mortality. Besides perinatal risk factors, initial and 12-hour lactate concentrations can be used for the early prediction of AKI.<\/jats:p>","DOI":"10.1055\/s-0039-1701024","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T23:39:19Z","timestamp":1580168359000},"page":"922-929","source":"Crossref","is-referenced-by-count":35,"title":["Acute Kidney Injury in Neonates with Perinatal Asphyxia Receiving Therapeutic Hypothermia"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-9030","authenticated-orcid":false,"given":"Ozlem","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Yucesoy","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"issue":"05","key":"ref1","first-page":"111","article-title":"Therapeutic hypothermia in asphyxiated newborn: its applicability, feasibility and accessibility in developing country India: a long way to go","volume":"3","author":"D Sharma","year":"2014","journal-title":"J Neonatal Biol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"e58834","DOI":"10.1371\/journal.pone.0058834","article-title":"Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis","volume":"8","author":"S S Pauliah","year":"2013","journal-title":"PLoS One"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0002-9378(70)90341-8","article-title":"Distribution of the circulation in the normal and asphyxiated fetal primate","volume":"108","author":"R E Behrman","year":"1970","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref4","first-page":"617","article-title":"Acute systemic organ injury in term infants after asphyxia","volume":"143","author":"J M Perlman","year":"1989","journal-title":"Am J Dis Child"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/BF00868721","article-title":"Nonoliguric and oliguric acute renal failure in asphyxiated term neonates","volume":"9","author":"M G Karlowicz","year":"1995","journal-title":"Pediatr Nephrol"},{"key":"ref6","first-page":"688","article-title":"Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy","volume":"99","author":"G D Hankins","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/tropej\/fmi017","article-title":"Evaluation of renal functions in asphyxiated newborns","volume":"51","author":"A Aggarwal","year":"2005","journal-title":"J Trop Pediatr"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1179\/146532811X12925735813922","article-title":"Evaluation of glomerular and tubular renal function in neonates with birth asphyxia","volume":"31","author":"S Kaur","year":"2011","journal-title":"Ann Trop Paediatr"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/pr.2013.230","article-title":"Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia","volume":"75","author":"S Sarkar","year":"2014","journal-title":"Pediatr Res"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3109\/0886022X.2016.1165070","article-title":"Urinary markers of acute kidney injury in newborns with perinatal asphyxia (.)","volume":"38","author":"M Y Oncel","year":"2016","journal-title":"Ren Fail"},{"issue":"15","key":"ref11","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.3109\/14767058.2015.1094785","article-title":"Does therapeutic hypothermia reduce acute kidney injury among term neonates with perinatal asphyxia?--a randomized controlled trial","volume":"29","author":"V Tanigasalam","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1016\/j.transproceed.2007.04.028","article-title":"The effect of body temperature in a rat model of renal ischemia-reperfusion injury","volume":"39","author":"M S Delbridge","year":"2007","journal-title":"Transplant Proc"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13054-018-2061-6","article-title":"Acute kidney injury and mild therapeutic hypothermia in patients after cardiopulmonary resuscitation - 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