{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:10:06Z","timestamp":1740161406037,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003In 2005 the Kompetenznetz H\u00e4morrhagische Diathese Ost published epidemiologic data about patients with haemophilia A (HA) and haemophilia B (HB) in the eastern part of Germany. This study provides data about the development of treatment in these patients over the past 10 years.<\/jats:p><jats:p>\n          Methods\u2003Data from 12 haemophilia centres in eastern Germany were retrospectively collected for the year 2015 from patients' records.<\/jats:p><jats:p>\n          Results\u2003We evaluated 413 patients (115 children, 298 adults) with HA or HB. A total of 286 patients (69.2%) had severe haemophilia (patients with severe haemophilia, PWSH). Compared with 2005, the proportion PWSH on prophylaxis increased from 90% to 98.8% in children and from 64% to 80.2% in adults. The use of plasma-derived factor concentrates decreased from &gt;70% to 55.3% in children and to 55.1% in adults. Mean annual factor consumption in PWSH without inhibitor was higher in 2015 compared with 2005 (children with HA: 151,489 vs. 98,894; adults with HA: 217,151 vs. 151,394; children with HB: 105,200 vs. 64,256; adults with HB: 159,185 vs. 85,295). Median annualized bleeding (annualized bleeding rate, ABR) and joint bleeding rates (annualized joint bleeding rate, AJBR) in 2015 were 2 and 0 in children and 3 and 0 in adults, respectively. In 2015 only one child (1.2%) but 101 (53.2%) adults with severe haemophilia were anti-hepatitis C virus (anti-HCV) positive. The rate of anti-HCV positive patients with active hepatitis C dropped from 63.8% to 12.9%.<\/jats:p><jats:p>\n          Conclusions\u2003Within the last decade more patients with severe haemophilia were switched to a prophylactic regimen going along with a moderate increase in factor consumption achieving a low ABR and AJBR.<\/jats:p>","DOI":"10.1055\/s-0039-3399493","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T19:00:33Z","timestamp":1573498833000},"page":"119-127","source":"Crossref","is-referenced-by-count":3,"title":["Development of Haemophilia Treatment in the Eastern Part of Germany over the Last Decade in the Kompetenznetz H\u00e4morrhagische Diathese Ost (KHDO)"],"prefix":"10.1055","volume":"40","author":[{"given":"Rebecca","family":"Mahn","sequence":"additional","affiliation":[{"name":"Medical Department I, Division of Haemostaseology, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Schilling","sequence":"additional","affiliation":[{"name":"Divison of Haematology and Oncology, University Hospital Jena, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klamroth","sequence":"additional","affiliation":[{"name":"Vivantes Hospital in Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Kentouche","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Jena, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Aumann","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Sirb","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, DRK Hospital Lichtenstein, Lichtenstein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Scholz","sequence":"additional","affiliation":[{"name":"Centre of Coagulation Disorders, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolin","family":"Trautmann","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, University Hospital Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Halm-Heinrich","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Krammer-Steiner","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Rostock South City Medical Centre, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Koscielny","sequence":"additional","affiliation":[{"name":"Haemophilia Centre (EHCCC) with outpatient ambulance in the ambulance service (AGZ) of the Charit\u00e9, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Kreibich","sequence":"additional","affiliation":[{"name":"Haemophilia Ambulance, Heinrich Braun Hospital, Zwickau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Pietrzak-B\u00fcttner","sequence":"additional","affiliation":[{"name":"Paediatric Clinic, SRH Hospital Suhl, Suhl, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Tregel","sequence":"additional","affiliation":[{"name":"Ruppin General Hospital, Institute of Laboratory Medicine, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Kn\u00f6fler","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Hospital Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Pfrepper","sequence":"additional","affiliation":[{"name":"Medical Department I, Division of Haemostaseology, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and the Kompetenznetzwerk H\u00e4morrhagische Diathese Ost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,11,11]]},"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3399493.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T18:40:36Z","timestamp":1581532836000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3399493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,2,12]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3399493","relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"type":"print","value":"0720-9355"},{"type":"electronic","value":"2567-5761"}],"subject":[],"published":{"date-parts":[[2019,11,11]]}}}