{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:18:42Z","timestamp":1781702322605,"version":"3.54.5"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Vitamin D is known to have immunomodulatory functions and has action on chronic inflammatory processes, such as nasal polyposis.<\/jats:p><jats:p>\n          Objective\u2003The present study assessed the levels of 25-hydroxy vitamin D and high-sensitivity C-reactive protein (hs-CRP) in patients with nasal polyposis, as compared with healthy control subjects, and identified their association with disease severity in nasal polyposis. It further assessed the levels of 25-hydroxyl vitamin D and hs-CRP in patients with nasal polyposis and atopy and compared it with patients with nasal polyposis without atopy.<\/jats:p><jats:p>\n          Methods\u2003This was a cross-sectional study involving 2 groups: 80 patients with nasal polyposis and 80 healthy subjects. In patients with nasal polyposis, the disease severity is assessed by the sino-nasal outcome test (SNOT20) and by the Lund &amp; Mackay staging system. Levels of 25-hydroxy vitamin D and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA).<\/jats:p><jats:p>\n          Result\u2003The mean 25-hydroxyl vitamin D levels (ng\/ml) was 12.01\u2009\u00b1\u20097.29 for cases and 22.87\u2009\u00b1\u200914.95 for controls, with p\u2009&lt;\u20090.0001. The mean hs-CRP levels (mg\/L) was 5.99\u2009\u00b1\u20092.74 in cases and 2.41\u2009\u00b1\u20091.95 in controls, with p\u2009&lt;\u20090.0001. The severity of polyposis correlated negatively with serum levels of 25-hydroxy vitamin D and positively with hs-CRP.<\/jats:p><jats:p>\n          Conclusion\u2003The study has thus shown significant correlation between vitamin D deficiency and inflammation in patients with nasal polyps.<\/jats:p>","DOI":"10.1055\/s-0039-3399541","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:02:42Z","timestamp":1576832562000},"page":"e308-e312","source":"Crossref","is-referenced-by-count":8,"title":["25-Hydroxyl Vitamin D Deficiency in Nasal Polyposis"],"prefix":"10.1055","volume":"24","author":[{"given":"Ankur Kumar","family":"Chandrakar","sequence":"additional","affiliation":[{"name":"Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-4678","authenticated-orcid":false,"given":"Arun","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medha","family":"R.","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalaiselvi","family":"Rajendiran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00130832-200302000-00001","article-title":"Nasal polyposis: an update: editorial review","volume":"3","author":"R Pawankar","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/00016480600951368","article-title":"Eosinophil infiltration and activation in nasal polyposis","volume":"127","author":"G-K Fan","year":"2007","journal-title":"Acta 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