{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:32:51Z","timestamp":1772109171336,"version":"3.50.1"},"reference-count":12,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Postsurgical device-related meningitis caused by multidrug-resistant coagulase-negative staphylococci often complicates the treatment options. We report a rare and, to our knowledge, the first clinical case report of drain-associated meningitis caused by methicillin- and linezolid-resistant <jats:italic>Staphylococcus haemolyticus<\/jats:italic> following linezolid therapy in a vancomycin-hypersensitive patient subsequently treated with cotrimoxazole, resulting in clinical improvement. The molecular mechanisms responsible for linezolid resistance were found to be the presence of G2576T mutation in domain V of 23srRNA region, which often arises during linezolid usage and also carriage of <jats:italic>cfr<\/jats:italic> gene, which promotes resistance independent of antibiotic pressure. We emphasize on monitoring the rational use of linezolid to avoid the spread of resistance and also comprehensive perioperative care to prevent health care-associated infection.<\/jats:p>","DOI":"10.1055\/s-0039-3399599","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T23:46:57Z","timestamp":1576108017000},"page":"718-720","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Device-Associated Meningitis by Linezolid-Resistant <i>Staphylococcus haemolyticus<\/i> in a Vancomycin- Hypersensitive Patient"],"prefix":"10.25259","volume":"10","author":[{"given":"Priya","family":"Vijayan","sequence":"first","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwarakanath","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarathna","family":"Siddaiah","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena Kumari Haradara","family":"Bahubali","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"10.1055\/s-0039-3399599\/ref-1","doi-asserted-by":"crossref","first-page":"S927","DOI":"10.4103\/2152-7806.195228","article-title":"Post-neurosurgical meningitis: management of cerebrospinal fluid drainage catheters influences the evolution of infection","volume":"7","author":"Soavi","year":"2016","journal-title":"Surg Neurol Int"},{"issue":"11","key":"10.1055\/s-0039-3399599\/ref-2","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1099\/mic.0.000178","article-title":"Staphylococcus haemo-lyticus - an emerging threat in the twilight of the antibiotics age","volume":"161","author":"Czekaj","year":"2015","journal-title":"Microbiology"},{"issue":"1","key":"10.1055\/s-0039-3399599\/ref-3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jac\/dks354","article-title":"The emerging problem of linezolid-resistant Staphylococcus","volume":"68","author":"Gu","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1055\/s-0039-3399599\/ref-4","first-page":"115","article-title":"16S\/23S rRNA sequencing","author":"Lane","year":"1991","edition":"eds."},{"issue":"2","key":"10.1055\/s-0039-3399599\/ref-5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1086\/421471","article-title":"Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA","volume":"190","author":"Meka","year":"2004","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1055\/s-0039-3399599\/ref-6","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1128\/AAC.50.4.1156-1163.2006","article-title":"Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates","volume":"50","author":"Kehrenberg","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1055\/s-0039-3399599\/ref-7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/sur.2012.091","article-title":"Vancomycin versus linezolid in the treatment of methicillin-resistant. Staphylococcus aureus. meningitis","volume":"14","author":"Sipahi","year":"2013","journal-title":"Surg Infect (Larchmt)"},{"issue":"8","key":"10.1055\/s-0039-3399599\/ref-8","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1128\/AAC.00153-11","article-title":"Low fitness cost of the multidrug resistance gene cfr","volume":"55","author":"LaMarre","year":"2011","journal-title":"Antimicrob Agents Chemo-ther"},{"issue":"3","key":"10.1055\/s-0039-3399599\/ref-9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jac\/dkp494","article-title":"Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients","volume":"65","author":"Hill","year":"2010","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1055\/s-0039-3399599\/ref-10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0255-0857.148371","article-title":"Detection of the classical G2576U mutation in linezolid resistant Staphylococcus aureus along with isolation of linezolid resistant Enterococcus faecium from a patient on short-term linezolid therapy: first report from India","volume":"33","author":"Rai","year":"2015","journal-title":"Indian J Med Microbiol"},{"issue":"1","key":"10.1055\/s-0039-3399599\/ref-11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.diagmicrobio.2013.01.021","article-title":"Daptomycin plus trimethoprim\/sulfamethoxazole combination therapy in post-neurosurgical meningitis caused by linezolid-resistant Staphylococcus epidermidis","volume":"76","author":"Vena","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"3","key":"10.1055\/s-0039-3399599\/ref-12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/0974-2727.208261","article-title":"Cotrimoxazolea wonder drug in the era of multiresistance: case report and review of literature","volume":"9","author":"Batra","year":"2017","journal-title":"J Lab Physicians"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/device-associated-meningitis-by-linezolid-resistant-staphylococcus-haemolyticus-in-a-vancomycin-hypersensitive-patient\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/device-associated-meningitis-by-linezolid-resistant-staphylococcus-haemolyticus-in-a-vancomycin-hypersensitive-patient\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:41:48Z","timestamp":1691210508000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/device-associated-meningitis-by-linezolid-resistant-staphylococcus-haemolyticus-in-a-vancomycin-hypersensitive-patient\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":12,"alternative-id":["10.1055\/s-0039-3399599"],"URL":"https:\/\/doi.org\/10.1055\/s-0039-3399599","relation":{},"ISSN":["0976-3147"],"issn-type":[{"value":"0976-3147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"article-number":"718"}}