{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:19:43Z","timestamp":1783523983831,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#310030\u2013135815"],"award-info":[{"award-number":["#310030\u2013135815"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#310030\u2013118245"],"award-info":[{"award-number":["#310030\u2013118245"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#32003B-134963\/1"],"award-info":[{"award-number":["#32003B-134963\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#310030\u20131659"],"award-info":[{"award-number":["#310030\u20131659"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#310030\u2013165990"],"award-info":[{"award-number":["#310030\u2013165990"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#310030_175546"],"award-info":[{"award-number":["#310030_175546"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss Heart Foundation"},{"name":"Holcim Stiftung"},{"name":"Alfred and Annemarie von Sick Grants for Translational and Clinical Research Cardiology and Oncology"},{"name":"Foundation for Cardiovascular Research \u2013 Zurich Heart House"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischemia\/reperfusion (I\/R) injury in acute myocardial infarction activates several deleterious molecular mechanisms. The transcription factor JunD regulates pathways involved in oxidative stress as well as in cellular proliferation, differentiation, and death. The present study investigated the potential role of JunD as a modulator of myocardial injury pathways in a mouse model of cardiac I\/R injury. Infarct size, systemic and local inflammation, and production of reactive oxygen species, as well as cytosolic and mitochondrial apoptotic pathways were investigated in adult males after myocardial I\/R. In wild-type (WT) mice, 30\u2009minutes after ischemia and up to 24\u2009hours following reperfusion, cardiac JunD messenger ribonucleic acid expression was reduced while JunB increased. Cardiac-specific JunD overexpressing mice (JunDTg\/0\n          ) displayed larger infarcts compared with WT. However, postischemic inflammatory or oxidative responses did not differ. JunD overexpression reduced Sirt3 transcription by binding to its promoter, thus leading to mitochondrial dysfunction, myocardial cell death, and increased infarct size. On the other hand, JunD silencing reduced, while Sirt3 silencing increased infarct size. In human myocardial autopsy specimens, JunD-positive areas within the infarcted left ventricle staining corresponded to undetectable Sirt3 areas in consecutive sections of the same heart. Cardiac-specific JunD overexpression increases myocardial infarct size following I\/R. These effects are mediated via Sirt3 transcriptional repression, mitochondrial swelling, and increased apoptosis, suggesting that JunD is a key regulator of myocardial I\/R injury. The present data set the stage for further investigation of the potential role of Sirt3 activation as a novel target for the treatment of acute myocardial infarction.<\/jats:p>","DOI":"10.1055\/s-0039-3400299","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T04:05:57Z","timestamp":1576814757000},"page":"168-180","source":"Crossref","is-referenced-by-count":17,"title":["Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia\/Reperfusion Cardiac Injury by Downregulating Sirt3"],"prefix":"10.1055","volume":"120","author":[{"given":"Alexander","family":"Akhmedov","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Montecucco","sequence":"additional","affiliation":[{"name":"First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genoa\u2013Italian Cardiovascular Network, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Costantino","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Vdovenko","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Schaub Clerigu\u00e9","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Gaul","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Burger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Carbone","sequence":"additional","affiliation":[{"name":"First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-7975","authenticated-orcid":false,"given":"Luca","family":"Liberale","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Amrollahi-Sharifabadi","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University 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of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland"},{"name":"Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey A.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Division of Radiology, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Vall\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Radiology, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland"},{"name":"Department of Cardiology, University 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