{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:29:41Z","timestamp":1773502181756,"version":"3.50.1"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["CDT 142654"],"award-info":[{"award-number":["CDT 142654"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Risk factors for venous thromboembolism in patients with solid tumors are well studied; however, studies in patients with acute leukemia are lacking. We conducted a retrospective cohort study of adult patients diagnosed with acute myeloid leukemia and acute lymphoblastic leukemia diagnosed between June 2006 and June 2017 at a tertiary care center in Canada. Potential predictors of venous thromboembolism were evaluated using logistic regression and a risk score was derived based on weighed variables and compared using survival analysis. Internal validation was conducted using nonparametric bootstrapping. A total of 501 leukemia patients (427 myeloid and 74 lymphoblastic) were included. Venous thromboembolism occurred in 77(15.3%) patients with 71 events occurring in the first year. A prediction score was derived and validated and it included: previous history of venous thromboembolism (3 points), lymphoblastic leukemia (2 points), and platelet count\u2009&gt;\u200950\u2009\u00d7\u2009109\/L at the time of diagnosis (1 point). The overall cumulative incidence of venous thromboembolism was 44% in the high-risk group (\u2265 3 points) versus 10.5% in the low-risk group (0\u20132 points) and it was consistent at different follow-up periods (log-rank p\u2009&lt;\u20090.001). We derived and internally validated a predictive score of venous thromboembolism risk in acute leukemia patients.<\/jats:p>","DOI":"10.1055\/s-0039-3400303","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T23:32:55Z","timestamp":1577921575000},"page":"322-328","source":"Crossref","is-referenced-by-count":29,"title":["Development of a Clinical Prediction Rule for Venous Thromboembolism in Patients with Acute Leukemia"],"prefix":"10.1055","volume":"120","author":[{"given":"Fatimah","family":"Al-Ani","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin Pearl","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-8431","authenticated-orcid":false,"given":"Alejandro","family":"Lazo-Langner","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Western University, London, Ontario, Canada"},{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/archinte.166.4.458","article-title":"Incidence of venous thromboembolism and its effect on survival among patients with common cancers","volume":"166","author":"H K Chew","year":"2006","journal-title":"Arch Intern Med"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/CCO.0b013e3283592331","article-title":"Venous thromboembolism in the hematologic malignancies","volume":"24","author":"A Falanga","year":"2012","journal-title":"Curr Opin Oncol"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2007-10-116327","article-title":"Development and validation of a predictive model for chemotherapy-associated thrombosis","volume":"111","author":"A A Khorana","year":"2008","journal-title":"Blood"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2007.02374.x","article-title":"Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy","volume":"5","author":"A A Khorana","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"25","key":"ref5","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJM200012213432504","article-title":"Prognosis of cancers associated with venous thromboembolism","volume":"343","author":"H T S\u00f8rensen","year":"2000","journal-title":"N Engl J Med"},{"issue":"17","key":"ref6","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1182\/blood-2008-08-175745","article-title":"Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival","volume":"113","author":"G H Ku","year":"2009","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.thromres.2004.07.016","article-title":"Symptomatic venous thromboembolism in acute leukemia. 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