{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:43:06Z","timestamp":1794256986602,"version":"4.9.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Cincinnati Children's Hospital Center for Acute Care Nephrology"},{"name":"The Pediatric and Infant Center for Acute Nephrology"},{"name":"Clinical and Translational Science Center at The University of New Mexico","award":["UL1TR001449"],"award-info":[{"award-number":["UL1TR001449"]}]},{"name":"University of Iowa Institute for Clinical and Translational Science","award":["U54TR001356"],"award-info":[{"award-number":["U54TR001356"]}]},{"name":"Canberra Hospital Private Practice Fund","award":["100 Women Who Care Grant"],"award-info":[{"award-number":["100 Women Who Care Grant"]}]},{"name":"100 Women Charitable Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born &lt;32 weeks of gestational age (GA).<\/jats:p><jats:p>\n          Study Design\u2003Present study is a secondary analysis of premature infants born at &lt;32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort (n\u2009=\u2009546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD\/mortality.<\/jats:p><jats:p>\n          Results\u2003Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD\/death occurred in 246 of 546 (45%). For infants born \u226429 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI]\u2009=\u20090.47\u20132.86; p\u2009=\u20090.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD\/death that remained after controlling for multiple factors (adjusted OR\u2009=\u20094.21, 95% CI: 2.07\u20138.61; p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n          Conclusion\u2003Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD\/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.<\/jats:p>","DOI":"10.1055\/s-0039-3400311","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T21:06:19Z","timestamp":1574888779000},"page":"341-348","source":"Crossref","is-referenced-by-count":63,"title":["Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-8950","authenticated-orcid":false,"given":"Michelle C.","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Pediatrics, Division of Nephrology, Seattle Children's Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boohaker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie C.","family":"Eldredge","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology, Seattle Children's Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shina","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Nephrology, Seattle Children's Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Mayock","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Askenazi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Hingorani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Nephrology, Seattle Children's Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Neonatal Kidney Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,11,27]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3400311.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T18:37:26Z","timestamp":1582051046000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3400311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,27]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,2,18]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3400311","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,27]]}}}