{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:23:14Z","timestamp":1790644994741,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The use of antenatal magnesium sulfate (MgSO4) has been associated with neuroprotective effects. One of its' proposed mechanisms of action includes antagonism of calcium channels. Calcium influx is important for closure of ductus arteriosus. We hypothesized that antenatal MgSO4 exposure may be associated with an increased risk of hemodynamically significant patent ductus arteriosus (HsPDA) in premature infants (PI).<\/jats:p><jats:p>\n          Study Design\u2003A prospective cohort study conducted in two parts. PI (&lt; 32 weeks and\u2009&lt;\u20091,500\u2009g) were recruited (n\u2009=\u2009105). All infants had Echocardiograph (ECHO; within 3 days) and blood samples drawn at the same time for B-type natriuretic peptide (BNP; part 1) and NTproBNP (N-terminal pro BNP; part 2) measurements. HsPDA was defined as a PDA diameter\u2009&gt;\u20091.5\u2009mm and BNP levels\u2009&gt;\u200940 pg\/mL or NTproBNP\u2009&gt;\u200910,200 pg\/mL. Infants were divided into two groups based on antenatal MgSO4 exposure. Data were analyzed using SPSS 23. Difference in baseline characteristics and antenatal steroid use in the two groups was analyzed. A matched group analysis was performed to adjust for the difference in the numbers between the two groups. A p-value\u2009&lt;\u20090.05 was considered significant.<\/jats:p><jats:p>\n          Results\u2003There was no significant difference seen in baseline characteristics or use of antenatal steroids in exposed versus unexposed (n\u2009=\u200995 vs. n\u2009=\u200910). There was a significant negative correlation between antenatal MgSO4 exposure and HsPDA in PI (p \u2264 0.05). However, this association was not significant after matched group analysis.<\/jats:p><jats:p>\n          Conclusion\u2003Antenatal MgSO4 exposure is not associated with an increased risk of HsPDA. It may be associated with a decreased likelihood of HsPDA.<\/jats:p>","DOI":"10.1055\/s-0039-3400316","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:16:37Z","timestamp":1573758997000},"page":"e353-e356","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal Magnesium Sulfate Exposure and Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants"],"prefix":"10.1055","volume":"09","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-6705","authenticated-orcid":false,"given":"Amna","family":"Qasim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Aly","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,11,14]]},"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3400316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:16:37Z","timestamp":1573758997000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3400316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,10,15]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3400316","relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}