{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:57Z","timestamp":1740126837914,"version":"3.37.3"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Brandenburg State Ministry of Science, Research, and Culture"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Polymeric heart valves are constructed from flexible synthetic materials, therefore aiming to combine the advantageous hemodynamic of biological and the longevity of mechanical valve prostheses. One such valve prototype in development is the PIZZA valve constructed of flexible triangular silicone leaflets on a foldable metal base for perspective transcatheter implantation. Here we present further improvements in its performance through structural modifications.<\/jats:p><jats:p>\n          Methods\u2003Structurally modified prototypes were constructed from silicone sheets and stainless-steel wires. Their performance was then tested in a hemodynamic testing device of the type HKP 2.0.<\/jats:p><jats:p>\n          Results\u2003Shift from a planar to a cone shape as well as overlapping of the leaflets significantly improved the valves performance, reducing regurgitation as well as systolic pressure gradients.<\/jats:p><jats:p>\n          Conclusions\u2003The results of the modified prototypes expressed superior performance and represented a step forward on the road to an easily producible, polymeric transcatheter valvular prosthesis.<\/jats:p>","DOI":"10.1055\/s-0039-3400538","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:00:46Z","timestamp":1576832446000},"page":"043-048","source":"Crossref","is-referenced-by-count":2,"title":["Further Evolution of a New Nonbiological Transcatheter Valvular Prosthesis"],"prefix":"10.1055","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-3066","authenticated-orcid":false,"given":"Filip","family":"Schr\u00f6ter","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hartrumpf","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf-Uwe","family":"Kuehnel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roya","family":"Ostovar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes M.","family":"Albes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Complete replacement of the mitral valve. 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